1285535-52-5

Basic information

• Product Name: C₁₈H₂₀BrNO₃
• CAS NO: 1285535-52-5
• Molecular Weight: 378.266
• Mol File: 1285535-52-5.mol

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₀BrNO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₀BrNO₃(1285535-52-5)
• EPA Substance Registry System: C₁₈H₂₀BrNO₃(1285535-52-5)

Safety Data

• Hazardous Substances Data: 1285535-52-5(Hazardous Substances Data)

Upstream product

• 621-59-0 isovanillin 
• 1233979-40-2 C₁₅H₁₂BrClO₃ 
• 75-31-0 isopropylamine 
• 2973-58-2 2-bromoisovanillin 
• 38849-38-6 3-(benzyloxy)-2-bromo-4-methoxybenzaldehyde 
• 135586-17-3 3-(benzyloxy)-2-bromo-4-methoxybenzoic acid 

Downstream Products

• 1285535-47-8 6,6'-bis{2-[(3-chloro-4-fluorophenyl)amino]-2-oxoethoxy}-N,N'-diisopropyl-5,5'-dimethoxybiphenyl-2,2'-dicarboxamide 
• 1285535-48-9 5,5'-dimethoxy-N,N'-diisopropyl-6,6'-bis(2-oxo-2-{[3-(trifluoromethyl)phenyl]amino}ethoxy)biphenyl-2,2'-dicarboxamide 
• 1326579-50-3 6,6'-bis{2-[(3,4-dichlorophenyl)amino]-2-oxoethoxy}-5,5'-dimethoxy-N,N'-diisopropylbiphenyl-2,2'-dicarboxamide 
• 1326579-51-4 N,N'-diisopropyl-5,5'-dimethoxy-6,6'-bis{2-[(4-methoxyphenyl)amino]-2-oxoethoxy}biphenyl-2,2'-dicarboxamide 
• 1326579-54-7 6,6'-bis{2-[(4-bromophenyl)amino]-2-oxoethoxy}-N,N'-diisopropyl-5,5'-dimethoxybiphenyl-2,2'-dicarboxamide 
• 1326579-58-1 6,6'-bis{2-[(6-fluoropyridin-3-yl)amino]-2-oxoethoxy}-N,N'-diisopropyl-5,5'-dimethoxybiphenyl-2,2'-dicarboxamide 

Relevant articles and documents

Facile synthesis and biological evaluation of novel symmetrical biphenyls as Antitumor Agents

As a continuation to our previous work in developing anticancer agents, eighteen symmetrical biphenyl derivatives structurally related to taspine were synthesized and evaluated in vitro and in vivo. All the compounds were prepared with varied substitutions in the phenyl ring of aniline moiety. The cytotoxicity and anticancer activity of biphenyls was evaluated against various human tumor and normal cell line. Antiproliferative assays indicated that some of them exhibited potent anticancer activity. The potent antiproliferative activity of these compounds against ECV304 suggested that these biphenyls could be served as antiangiogenic agents. The highly active compound (2) also exhibited potent growth inhibition against cancer cell lines in vivo. Our findings demonstrated that these symmetrical biphenyl derivatives would be a promising candidate as novel anticancer agents.

Synthesis and cytotoxic evaluation of novel symmetrical taspine derivatives as anticancer agents

It has been demonstrated that taspine derivatives act as anticancer agents, thus we designed and synthesized a novel class of symmetrical biphenyl derivatives. We evaluated the cytotoxicity and antitumor activity of biphenyls against five human tumor and normal cell lines. The results indicated that the majority of the compounds exhibited anticancer activity equivalent to or greater than the positive control. Compounds (11) and (12) demonstrated the most potent cytotoxic activity with IC50 values between 19.41 μM and 29.27 μM. The potent antiproliferative capabilities of these compounds against ECV304 human transformed endothelial cells indicated that these biphenyls could potentially serve as antiangiogenic agents. We also reviewed the relationship between structure and activity based on the experimental results. Our findings provide a good starting point for further development of symmetrical biphenyl derivatives as potential novel anticancer agents.