1285535-54-7Relevant academic research and scientific papers
Copper-catalyzed hydroxylation of aryl halides with tetrabutylammonium hydroxide: Synthesis of substituted phenols and alkyl aryl ethers
Paul, Rajesh,Ali, Md Ashif,Punniyamurthy, Tharmalingam
supporting information; experimental part, p. 4268 - 4272 (2011/02/25)
The selective hydroxylation of aryl iodides and aryl bromides with tetrabutylammonium hydroxide pentahydrate is described. For this, the combination of copper(I) iodide and 8-hydroxyquinaldine at 70-130C in a mixture of dimethyl sulfoxide and water (2:3) is used. The resultant phenols can be readily reacted with alkyl and allyl halides in situ to provide the corresponding alkyl or allyl aryl ethers in high yields. The reactions are simple, general, and efficient, affording substituted phenols and alkyl aryl ethers under aerobic conditions
