1285536-15-3Relevant academic research and scientific papers
A highly enantioselective zirconium catalyst for intramolecular alkene hydroamination: Significant isotope effects on rate and stereoselectivity
Manna, Kuntal,Xu, Songchen,Sadow, Aaron D.
, p. 1865 - 1868 (2011)
Zirconium catalysts sparkle: A new chiral zirconium complex has been used to catalyze hydroamination reactions to cyclize aminopentenes into 2-methylpyrrolidines (see scheme). The rate law supports a mechanism involving a reversible substrate-catalyst interaction that precedes the rate-determining step. A new mechanism for zirconium-catalyzed hydroamination has been proposed based on kinetic isotope effects and the significant effect of isotopic substitution on enantioselectivity.
