128562-57-2Relevant academic research and scientific papers
A Chiral Route to Both Enantiomers of Physostigmine and the First Synthesis of (-)-Norphysostigmine
Takano, Seiichi,Moriya, Minoru,Iwabuchi, Yoshiharu,Ogasawara, Kunio
, p. 109 - 112 (2007/10/02)
A chiral route to both enantiomers of esermethol, the key synthetic precursor of physostigmine, has been established starting from (S)-O-benzylglycidol via separation of the diastereomeric intermediates. (-)-Physostigmine obtainable from the (-)-enantiomer has been first transformed into (-)-norphysostigmine, the onyl unsynthesized member of the alkaloid group ever determined.
