128564-82-9Relevant academic research and scientific papers
Synthesis and cardiotonic activity of 2-indolinones
Andreani, Aldo,Rambaldi, Mirella,Locatelli, Alessandre,Bossa, Rosaria,Galatulas, Iraklis,Ninci, Mauro
, p. 187 - 190 (2007/10/02)
The paper reports the synthesis of 3-(2,5-dimethoxybenzylidene)- 2 and 3-(4-pyridylmethylene)-2-indolinones 3 which, as expected, proved to have significant positive inotropic activity.On the contrary, 3-(2,5-dimethoxybenzyl)- 4 and 3-(4-pyridylmethyl)-2-indolinones 5, obtained by reduction of the corresponding compounds 2 and 3, were devoid of cardiotonic activity.
