128584-46-3

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 37436-94-5 (7-chloro-1⁽³⁾H-imidazo[4,5-b]pyridin-5-yl)-carbamic acid ethyl ester 

Relevant academic research and scientific papers

IMIDAZO[4,5-B]PYRIDINE DERIVATIVES AS CARDIOVASCULAR AGENTS

Disclosed are the compounds of the formula STR1 wherein R represents hydrogen, lower alkyl, aryl or aryl-lower alkyl; R 1 represents hydrogen, lower alkyl, C 3-C 7-alkenyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, C 3-C 7-cycloalkyl, or optionally lower alkyl substituted (C 3-C. sub.7-cycloalkyl, bicycloheptyl, bicycloheptenyl, adamantyl, tetrahydropyranyl or tetrahydrothiopyranyl)-lower alkyl, or diaryl-lower alkyl; R 2 represents hydrogen or lower alkyl; R 3 represents hydroxymethyl or--CONHR 4 in which R 4 represents hydrogen, lower alkyl, aryl-lower alkyl, C 3-C 7-cycloalkyl, C 3-C. sub.7-cycloalkyl-lower alkyl or hydroxy-lower alkyl; pharmaceutically acceptable ester derivatives thereof in which one or more of the hydroxy groups are esterified in form of a pharmaceutically acceptable ester; and pharmaceutically acceptable salts thereof; methods of preparation; pharmaceutical compositions; and their use as adenosine-2 agonists in mammals.