128592-50-7Relevant academic research and scientific papers
Diastereoselective addition of organometallic reagents to chiral iminium ions: Synthesis of (S)-(+)-cryptostyline I
Polniaszek, Richard P.,Dillard, Lawrence W.
, p. 797 - 800 (2007/10/02)
Iminium ion 2c participates in stereoselective nucleophilic addition reactions with Grignard reagents. Analysis of the products from reaction of 5-hexenylmagnesium bromide with iminium ion 2a suggests that these reactions proceed by a polar (two electron) mechanism. The utility of this chemistry is demonstrated in a stereo specific synthesis of (5)-(+)-cryptostylina I.
Stereoselective Nucleophilic Additions to the Carbon-Nitrogen Double Bond. 2. Chiral Iminium Ions Derived from "Second Generation" Chiral Amines
Polniaszek, Richard P.,Kaufman, Craig R.
, p. 4859 - 4863 (2007/10/02)
"Second generation" chiral amines (1S)-(-)-1-(2-chlorophenyl)ethylamine (4) and (1S)-(-)-1-(2,6-dichlorophenyl)ethylamine (5) have been prepared from commercially available (S)-(-)-α-phenethylamine.These chiral reagents have been incorporated into chiral
