128595-81-3Relevant academic research and scientific papers
RADIOLABELED PHARMACEUTICALS AND METHODS OF MAKING AND USING SAME
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Page/Page column 32-34, (2018/09/12)
In one aspect, the invention comprises compounds that bind to the synaptic vesicle protein SV2A and that can be useful as radiotracers for positron emission tomography. In another aspect, the invention comprises methods of imaging the brain, measuring synaptic density or diagnosing neurological diseases such as Alzheimer's disease, psychiatric disorders such as depression, and metabolic disorders such as diabetes comprising detecting the compounds of the invention by positron emission tomography (PET).
Design, synthesis, and biological evaluation of 4-(5-dimethylamino-naphthalene-1-sulfon-amido)-3-(4-iodophenyl)butanoic acid as a novel molecular probe for apoptosis imaging
Zeng, Wenbin,Miao, Weimin,Le Puil, Michael,Shi, Guangqing,Biggerstaff, John,Kabalka, George W.,Townsend, David
experimental part, p. 571 - 575 (2011/10/10)
Apoptosis (programmed cell death) plays a crucial role in the pathogenesis of many disorders, thus the detection of apoptotic cells can provide the physician with important information to further therapeutic strategies and would substantially advance pati
