128598-93-6Relevant academic research and scientific papers
Diastereoselective addition of organometallic reagents to chiral iminium ions: Synthesis of (S)-(+)-cryptostyline I
Polniaszek, Richard P.,Dillard, Lawrence W.
, p. 797 - 800 (2007/10/02)
Iminium ion 2c participates in stereoselective nucleophilic addition reactions with Grignard reagents. Analysis of the products from reaction of 5-hexenylmagnesium bromide with iminium ion 2a suggests that these reactions proceed by a polar (two electron) mechanism. The utility of this chemistry is demonstrated in a stereo specific synthesis of (5)-(+)-cryptostylina I.
