128599-54-2Relevant academic research and scientific papers
Organocatalytic Imidazolium Ionic Liquids H/D Exchange Catalysts
Zanatta, Marcileia,Dos Santos, Francisco P.,Biehl, Cristina,Marin, Graciane,Ebeling, Gunter,Netz, Paulo A.,Dupont, Jairton
supporting information, p. 2622 - 2629 (2017/03/14)
Simple 1,2,3-trialkylimidazolium cation associated with basic anions, such as hydrogen carbonate, prolinate, and imidazolate, is an active catalyst for the H/D exchange reaction of various substrates using CDCl3 as D source, without the addition of any extra bases or metal. High deuterium incorporation (up to 49%) in acidic C-H bonds of ketone and alkyne substrates (pKa from 18.7 to 28.8) was found at room temperature. The reaction proceeds through the fast and reversible deuteration of the 2-methyl H of the imidazolium cation followed by D transfer to the substrate. The IL acts as a neutral base catalyst in which the contact ion pair is maintained in the course of the reaction. The basic active site is due to the presence of a remote basic site in the anion namely, OH of bicarbonate, NH of prolinate, and activated water in the imidazolate anion. Detailed kinetic experiments demonstrate that the reaction is first order on the substrate and pseudozero order relative to the ionic liquid, due to the fast reversible reaction involving the deuteration of the ionic liquid by the solvent.
SPIRO-THIAZOLONES
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Page/Page column 78; 79, (2016/06/06)
The present invention provides spiro-thiazolones, which act as V1a receptor modulators, and in particular as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The present compounds are useful as therapeutics acting peripherally and centrally in the conditions of inappropriate secretion of vasopressin, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, aggressive behavior and phase shift sleep disorders, in particular jetlag.
An investigation of the conformation of 4-chloroethylbenzene as a solut e in a nematic liquid crystalline solvent
Celebre, G.,Luca, G. De,Longeri, M.,Catalano, D.,Lumetti, M.,Emsley, J.W.
, p. 221 - 231 (2007/10/02)
The conformation of the ethyl group relative to the phenyl ring plane in 4-chloroethylbenzene has been investigated by recording and analysing the proton NMR spectrum of a sample dissolved in a nematic liquid crystalline solvent.The dipolar couplings obta
