128627-95-2

Upstream product

• 40315-17-1 Acetonedicarboxylic acid dianilide 
• 109-77-3 malononitrile 
• 128627-94-1 (6-amino-5-cyano-1,2-dihydro-2-oxo-1-phenylpyrid-4-yl)-acetanilide 

Downstream Products

• 128628-00-2 8-amino-1,6-diphenyl-1,2,4,5,6,7-hexahydro-7-imino-pyrido<3,4-c>pyridine-2,4,5-trione-4-phenylhydrazone 
• 128628-02-4 8-Amino-4-[(4-chloro-phenyl)-hydrazono]-1-imino-2,7-diphenyl-1,7-dihydro-2H,4H-[2,7]naphthyridine-3,6-dione 
• 128628-01-3 8-Amino-1-imino-4-[(4-methoxy-phenyl)-hydrazono]-2,7-diphenyl-1,7-dihydro-2H,4H-[2,7]naphthyridine-3,6-dione 

Relevant academic research and scientific papers

Reactions with β-Ketodianilides. I. New Synthesis of Pyridopyridine Derivatives

Acetonedicarboxylic acid dianiline reacted with malononitrile, ethyl cyanoacetate or benzoylacetonitrile to give (6-amino-5-cyano-1,2-dihydro-2-oxo-1-phenylpyrid-4-yl)-acetanilide (3), (3-cyano-2,6-dioxo-1-phenyl-1,2,5,6-tetrahydropyrid-4-yl)acetanilide (8) or (3-cyano-1,6-dihydro-1,2-diphenyl-6-oxopyrid-4-yl)acetanilide (9).Compounds 3 and 8 could be cyclised into 8-amino-1,6-diphenyl-1,2,4,5,6,7-hexahydro-7-iminopyridopyridine-2,5-dione (4) and 7-amino-1,2,3,5,6,8-hexahydro-1,6-diphenylpyridopyridine-2,5,8-trione (10) respectively by heating their solutions in dimethylformamide in the presence of triethylamine.Each of 3 and 4 coupled with arenediazonium chlorides to give the corresponding arylhydrazone derivatives (5a-d) and (6a-c), respectively.Condensation of 4 with p-nitrosodimethylaniline yielded 8-amino-4-(p-dimethylaminophenylimino)-1,6-diphenyl-1,2,4,5,6,7-hexahydro-7-iminopyridopyridine-2,5-dione (7).