128632-84-8

Basic information

• Product Name: {(3R,6S,15S)-3-Benzyl-15-[(R)-1-(2,2-dimethyl-propylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-2,5,9-trioxo-1,4,10-triaza-cyclopentadec-6-yl}-carbamic acid benzyl ester
• Synonyms: {(3R,6S,15S)-3-Benzyl-15-[(R)-1-(2,2-dimethyl-propylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-2,5,9-trioxo-1,4,10-triaza-cyclopentadec-6-yl}-carbamic acid benzyl ester
• CAS NO: 128632-84-8
• Molecular Weight: 793.963
• Mol File: 128632-84-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {(3R,6S,15S)-3-Benzyl-15-[(R)-1-(2,2-dimethyl-propylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-2,5,9-trioxo-1,4,10-triaza-cyclopentadec-6-yl}-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {(3R,6S,15S)-3-Benzyl-15-[(R)-1-(2,2-dimethyl-propylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-2,5,9-trioxo-1,4,10-triaza-cyclopentadec-6-yl}-carbamic acid benzyl ester(128632-84-8)
• EPA Substance Registry System: {(3R,6S,15S)-3-Benzyl-15-[(R)-1-(2,2-dimethyl-propylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-2,5,9-trioxo-1,4,10-triaza-cyclopentadec-6-yl}-carbamic acid benzyl ester(128632-84-8)

Safety Data

• Hazardous Substances Data: 128632-84-8(Hazardous Substances Data)

Upstream product

• 4299-70-1 D-Tryptophan methyl ester 
• 128659-43-8 Z-Glu-D-Phe-Lys-D-Trp-OMe*HCl 
• 128633-24-9 Z-Glu(OBu^t)-D-Phe-Lys(Boc)-D-Trp-OMe 
• 128632-80-4 (R)-2-[((2R,5S,14S)-2-Benzyl-14-benzyloxycarbonylamino-3,11,15-trioxo-1,4,10-triaza-cyclopentadecane-5-carbonyl)-amino]-3-(1H-indol-3-yl)-propionic acid methyl ester 
• 128633-23-8 Z-D-Phe-Lys(Boc)-D-Trp-OMe 
• 31008-46-5 (R)-2-((S)-2-Benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoylamino)-3-(1H-indol-3-yl)-propionic acid methyl ester 
• 50843-04-4 Lys(Boc)-D-Trp-OMe 
• 2448-45-5 Cbz-D-Phe 
• 3886-08-6 5-tert-butyl N-benzyloxycarbonyl-L-glutamate 
• 2389-60-8 Z-Lys(Boc)-OH 
• 5813-64-9 2.2-dimethylpropylamine 
• 128633-25-0 (R)-2-[((2R,5S,14S)-2-Benzyl-14-benzyloxycarbonylamino-3,11,15-trioxo-1,4,10-triaza-cyclopentadecane-5-carbonyl)-amino]-3-(1H-indol-3-yl)-propionic acid 

Relevant articles and documents

Novel Inhibitors of Human Renin. Cyclic Peptides Based on the Tetrapeptide Sequence Glu-D-Phe-Lys-D-Trp

Cyclic peptide inhibitors of human renin based on a linear peptide, Boc-D-Phe-Cys(Acm)-D-Trp-Leu-OMe (1), were prepared by solution-phase methods.Potent inhibitors were obtained in one series of compounds, (3), in which the D-phenylalanine residue was incorporated in a 15-membered ring structure.Any reductions or enlargements of the ring size led to inactive or less potent peptides.The most potent inhibitor of human renin, (31) (IC50 6.3 * 10-8M), was obtained by changing N- and C-terminal parts of pentapeptide 3.It was about 650-fold more potent than linear tetrapeptide 1 and about 50-fold more potent than cyclic peptide 3.Compound 31 was also 112-fold more potent against human renin than against porcine renin.