128641-02-1

Basic information

• Product Name: 5-carbonitrile-1,6-dihydro-4-(3-fluorophenyl)-2-(methylthio)-6-oxopyrimidine
• Synonyms: 5-carbonitrile-1,6-dihydro-4-(3-fluorophenyl)-2-(methylthio)-6-oxopyrimidine
• CAS NO: 128641-02-1
• Molecular Weight: 261.279
• Mol File: 128641-02-1.mol

Chemical Properties

• CAS DataBase Reference: 5-carbonitrile-1,6-dihydro-4-(3-fluorophenyl)-2-(methylthio)-6-oxopyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-carbonitrile-1,6-dihydro-4-(3-fluorophenyl)-2-(methylthio)-6-oxopyrimidine(128641-02-1)
• EPA Substance Registry System: 5-carbonitrile-1,6-dihydro-4-(3-fluorophenyl)-2-(methylthio)-6-oxopyrimidine(128641-02-1)

Safety Data

• Hazardous Substances Data: 128641-02-1(Hazardous Substances Data)

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 456-48-4 3-Fluorobenzaldehyde 
• 128640-95-9 6-(3-fluorophenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile 
• 74-88-4 methyl iodide 

Downstream Products

• 128641-48-5 2,4-dimethylthio-6-(3-fluorophenyl)pyrimidine-5-carbonitrile 
• 128641-47-4 6-(3-fluorophenyl)-2-methylthio-4-thiopyrimidine-5-carbonitrile 
• 898254-63-2 ethyl 5-amino-4-(3-fluorophenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxylate 
• 898254-68-7 5-amino-4-(3-fluoro-phenyl)-2-methylsulfanyl-thieno[2,3-d]pyrimidine-6-carboxylic acid 
• 128641-33-8 5-carbonitrile-4-chloro-6-(3-fluorophenyl)-2-(methylthio)pyrimidine 

Relevant articles and documents

Suitably functionalised pyrimidines as potential antimycotic agents

Various suitably functionalised pyrimidine derivatives have been synthesized to explore their potential as antimycotic agents. Some of the synthesized compounds 4c, 4d, 8a-e have shown highly significant in vitro antifungal activity against five human pathogenic fungi. (C) 2000 Elsevier Science Ltd. All rights reserved.

Synthesis and cytotoxic activity of novel 4-amino-5-cyano-2-sulfonylpyrimidines

Novel 4-amino-5-cyano-2-sulfonylpyrimidines were prepared based on three-component cyclization between isothiouronium salts, benzaldehydes and malononitrile, followed by oxidation of the sulfide moiety with Oxone. The cytotoxic activity of the synthesized compounds, as well as the induction of apoptosis, inhibition of the cell cycle and proliferation tests were performed on selected cancer cell lines A431, A549, A375, HCT 116, MCF7, LNCap and SH-SY5Y.

Chemotherapeutic Agents. XII - Synthesis of Pyrimidines and Fused Pyrimidines as Leishmanicides and Herbicides

Various bicyclic (2, 3) and tricyclic (4, 5) heterocycles were prepared by the reaction of 1a, c with dihaloalkanes and polynitrohalobenzene separately.Electrophilic substitution on 1a-c with different alkyl halides yielded mono and dialkyl pyrimidines (6-20).Nucleophilic substitution reactions on 18 and 21 with amine and hydrazine separately yielded 22-31, 21a, b and 41c.Reaction of 25a with ethyl ethoxymethylenecyanoacetate and chloroacetyl chloride separately provided bicyclic compounds 32 and 33.Condensation-cyclization of 25a with formic, acetic and nitrous acid separately yielded 34a, b and 35.Reaction of 26a with ethylthioglycolate and thiourea separately provided 36a and 39.The latter was alkylated with methyl iodide to 40.An attempt to cyclize 29a and 30a with thionyl chloride provided bicyclic compounds 37a, b and an uncyclic product 38.Some of the compounds were screened for leishmanicidal and herbicidal activities and a few of them exhibited significant activity.