128641-77-0

Basic information

• Product Name: N'-(6-chloro-3-pyridazinyl)-(3-trifluoromethyl-benzoic hydrazide)
• Synonyms: N'-(6-chloro-3-pyridazinyl)-(3-trifluoromethyl-benzoic hydrazide)
• CAS NO: 128641-77-0
• Molecular Weight: 316.67
• Mol File: 128641-77-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N'-(6-chloro-3-pyridazinyl)-(3-trifluoromethyl-benzoic hydrazide)(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(6-chloro-3-pyridazinyl)-(3-trifluoromethyl-benzoic hydrazide)(128641-77-0)
• EPA Substance Registry System: N'-(6-chloro-3-pyridazinyl)-(3-trifluoromethyl-benzoic hydrazide)(128641-77-0)

Safety Data

• Hazardous Substances Data: 128641-77-0(Hazardous Substances Data)

Upstream product

• 17284-97-8 3-Chloro-6-hydrazinopyridazine 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 

Downstream Products

• 128641-75-8 6-morpholino-3-(3-trifluormethylphenyl)-1,2,4-triazolo<4,3-b>pyridazine 
• 128666-84-2 6-chloro-3-(3-trifluoromethylphenyl)-1,2,4-triazolo<4,3-b>pyridazine 

Relevant articles and documents

Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase

A series of substituted 3-aryl-6-amino-triazolo[4,3-b]pyridazines were identified as highly selective inhibitors of Pim-1 kinase. Initial exploration identified compound 24 as a potent, selective inhibitor, limited in its utility by poor solubility and permeability. Understanding the unusual ATP-binding site of the Pim kinases and X-ray crystallographic data on compound 24 led to design improvements in this class of inhibitor. This resulted in compound 29, a selective, soluble and permeable inhibitor of Pim-1.