128659-94-9Relevant academic research and scientific papers
Copper-Catalyzed Asymmetric Defluoroborylation of 1-(Trifluoromethyl)Alkenes
Gao, Pan,Yuan, Chengkai,Zhao, Yue,Shi, Zhuangzhi
, p. 2201 - 2211 (2018)
gem-Difluoroalkenes have steric and electronic profiles similar to those of ketones, aldehydes, and esters, and consequently have been used widely as carbonyl isosteres in modern drug discovery. Although many attempts have been made to achieve gem-difluor
A Copper(I)-Catalyzed Enantioselective γ-Boryl Substitution of Trifluoromethyl-Substituted Alkenes: Synthesis of Enantioenriched γ,γ-gem-Difluoroallylboronates
Kojima, Ryoto,Akiyama, Sota,Ito, Hajime
supporting information, p. 7196 - 7199 (2018/06/15)
The first catalytic enantioselective γ-boryl substitution of CF3-substituted alkenes is reported. A series of CF3-substituted alkenes was treated with a diboron reagent in the presence of a copper(I)/Josiphos catalyst to afford the c
