128666-82-0

Upstream product

• 128640-73-3 5-cyano-4-(3-methoxyphenyl)-2-methylthio-6-hydroxy-pyrimidine 
• 131890-31-8 6-(3-methoxyphenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile 
• 591-31-1 3-methoxy-benzaldehyde 
• 128640-73-3 5-carbonitrile-1,6-dihydro-4-(3-methoxyphenyl)-2-(methylthio)-6-oxopyrimidine 

Downstream Products

• 128640-75-5 3-amino-2-carbethoxy-6-ethoxy-4-(3-methoxyphenyl)thieno<2,3-d>pyrimidine 
• 301846-06-0 ethyl-5-amino-4-(3-methoxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxylate 
• 945001-45-6 C₁₇H₁₇N₅O₂S 
• 128640-78-8 2,4-dimethylthio-6-(3-methoxyphenyl)pyrimidine-5-carbonitrile 
• 898254-42-7 N'-Boc-5-amino-4-(3-methoxyphenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carbohydrazide 
• 301847-37-0 Org 41841 

Relevant academic research and scientific papers

Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors

The serine/threonine specific protein kinase B-Raf is part of the MAPK pathway and is an interesting oncology target. We have identified thieno[2,3-d]pyrimidines as a core scaffold of small molecule B-Raf inhibitors. The SAR of analogs in this series will be described.

PYRIMIDINE LOW MOLECULAR WEIGHT LIGANDS FOR MODULATING HORMONE RECEPTORS

Disclosed herein are small molecule modulators hormone receptors, including agonists and antagonists of luteinizing hormone/choriogonadotropin, follicle stimulating hormone and thyroid stimulating hormone receptors. Exemplary disclosed compounds include t

Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: Structure-activity relationships and selective binding patterns

The substituted thieno[2,3-d]pyrimidine 3 (Org 41841), a partial agonist for the luteinizing hormone/choriogonadotropin receptor (LHCGR) and the closely related thyroid-stimulating hormone receptor (TSHR), was fundamentally altered, and the resulting anal

Bicyclic heteroaromatic compounds

A bicyclic heteroaromatic compound according to general formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, (6-14C)aryl or (4-13C)heteroaryl; all optionally substituted with one or

Metalation of diazines X: First halogen migration during metalation of pyrimidines unusual halogen-lithium exchange with LTMP new synthesis of Leshmaniacides

An halogen migration of iodine during the metalation of pyrimidines has been highlighted and a mechanism is proposed. An unusual halogen-lithium exchange with LTMP has been observed. A new synthetic route to Leshmaniacides using metalation and cross coupl

Chemotherapeutic Agents. XVI. Synthesis of Pyrimidines and Fused Pyrimidines as Leishmanicides

Various mono and bicyclic pyrimidine analogs (3-15) were prepared as leishmanicides from 6-aryl-4-chloro-2-methylthiopyrimidine-5-carbonitrile (2), obtained from the halogenation of 6-aryl-3,4-dihydro-2-methylthio-4-oxopyrimidine-5-carbonitrile (1).