128667-26-5

Basic information

• Product Name: 6-{3-[(4-Fluoro-benzyl)-methyl-amino]-2-hydroxy-propoxy}-1H-quinolin-2-one
• CAS NO: 128667-26-5
• Molecular Weight: 356.397
• Mol File: 128667-26-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-{3-[(4-Fluoro-benzyl)-methyl-amino]-2-hydroxy-propoxy}-1H-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-{3-[(4-Fluoro-benzyl)-methyl-amino]-2-hydroxy-propoxy}-1H-quinolin-2-one(128667-26-5)
• EPA Substance Registry System: 6-{3-[(4-Fluoro-benzyl)-methyl-amino]-2-hydroxy-propoxy}-1H-quinolin-2-one(128667-26-5)

Safety Data

• Hazardous Substances Data: 128667-26-5(Hazardous Substances Data)

Upstream product

• 405-66-3 (4-Fluoro-benzyl)-methyl-amine 
• 128668-84-8 6-(2,3-epoxypropoxy)-2(1H)-quinolinone 

Relevant articles and documents

Novel positive inotropic agents: Synthesis and biological activities of 6- (3-amino-2-hydroxypropoxy)-2(1H)-quinolinone derivatives

A series of 6-(3-amino-2-hydroxypropoxy)-2(1H)-quinolinones has been synthesized and evaluated for positive inotropic activity on the canine heart. Some of these derivatives have a potent activity with none or negative chronotropic effect in isolated, blood-perfused dog heart preparations. They also display a high selectivity for positive inotropic effect over chronotropic and vasodilatory effects in anesthetized dogs. (±)-6-[2- Hydroxy-3-[(3-methoxybenzyl)amino]propoxy]-2(1H)-quinolinone (39) and (±)-6- [3-(3,4-dimethoxybenzyl)amino]-2-hydroxypropoxy]-2(1H)-quinolinone (40) were further investigated in conscious dogs. After iv administration, they did not affect heart rate or mean blood pressure at the dose producing a 50% increase in the peak of the first derivative of the left ventricular pressure. The compounds (39, OPC-18750, and 40, OPC-18790) are the most promising agents with desirable biological activities, and now are currently undergoing clinical evaluation.