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1286670-38-9

5-((5-(4-chloro-3-(1H-tetrazol-5-yl)phenyl)furan-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1286670-38-9 Structure

  • Basic information

    1. Product Name: 5-((5-(4-chloro-3-(1H-tetrazol-5-yl)phenyl)furan-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-one
    2. Synonyms:
    3. CAS NO:1286670-38-9
    4. Molecular Formula:
    5. Molecular Weight: 533.942
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1286670-38-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-((5-(4-chloro-3-(1H-tetrazol-5-yl)phenyl)furan-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-((5-(4-chloro-3-(1H-tetrazol-5-yl)phenyl)furan-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-one(1286670-38-9)
    11. EPA Substance Registry System: 5-((5-(4-chloro-3-(1H-tetrazol-5-yl)phenyl)furan-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-4-one(1286670-38-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1286670-38-9(Hazardous Substances Data)

1286670-38-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1286670-38-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,8,6,6,7 and 0 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1286670-38:
(9*1)+(8*2)+(7*8)+(6*6)+(5*6)+(4*7)+(3*0)+(2*3)+(1*8)=189
189 % 10 = 9
So 1286670-38-9 is a valid CAS Registry Number.

1286670-38-9Downstream Products

1286670-38-9Relevant articles and documents

Design, synthesis, and biological activity of novel 5-((arylfuran/1 H -pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl) thiazolidin-4-ones as HIV-1 fusion inhibitors targeting gp41

Jiang, Shibo,Tala, Srinivasa R.,Lu, Hong,Abo-Dya, Nader E.,Avan, Ilker,Gyanda, Kapil,Lu, Lu,Katritzky, Alan R.,Debnath, Asim K.

, p. 572 - 579 (2011/03/20)

On the basis of our earlier molecular docking analysis, we designed and synthesized 5-((arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3- (trifluoromethyl)phenyl)thiazolidin-4-ones (12a-o) as HIV-1 entry inhibitors. Compounds 12a-o effectively inhibited infection by both laboratory-adapted and primary HIV-1 strains and blocked HIV-1 mediated cell-cell fusion and gp41 six-helix bundle formation. Molecular docking analyses on two highly active inhibitors, 12b, containing a carboxylic acid group, and 12m, containing a tetrazole group, indicated that they both fit snugly into the hydrophobic cavity of HIV-1 gp41 from which each has important ionic interactions with lysine 574 (K574). By contrast, molecular docking of 12i, a less active compound containing a pyrrole instead of a furan ring, indicated a completely different orientation from 12b and 12m and missed critical interactions.

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