1286727-45-4

Upstream product

• 1286727-42-1 C₂₁H₂₇F₂NO₃Si 
• 1349833-44-8 lithium (2S,3S,4S,5R,6S)-6-(4-((4-((3,7-dimethyloct-6-enyloxy)(phenethoxy)methyl)phenylcarbamoyloxy)-methyl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate 
• 1349833-31-3 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl 4-(benzyloxy(ethoxy)methyl)phenylcarbamate 
• 1349832-78-5 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl 4-(bis(benzyloxy)methyl)phenylcarbamate 
• 1349833-23-3 4-(tert-butyldimethylsilyloxy)benzyl 4-(dimethoxymethyl)phenylcarbamate 

Relevant academic research and scientific papers

A structurally simple self-immolative reagent that provides three distinct, simultaneous responses per detection event

A general design is presented for a stimulus-responsive small molecule that is capable of responding to a specific applied chemical or physical signal by releasing two different types of pendant small molecules and a colorimetric indicator simultaneously. A key aspect of this design is the ease with which these reagents are prepared: typically, only four synthetic steps are required. Moreover, the modular construction strategy provides access to stimuli-responsive reagents that are capable of (i) responding to a variety of applied signals and (ii) releasing a number of different small molecules that contain primary alcohols, secondary alcohols, or phenols. These stimuli-responsive reagents are stable under physiological conditions (neither hydrolysis nor thermal degradation of the reagent occurs in significant quantity), and when they are exposed to the appropriate applied signal, they release both pendant small molecules and the colorimetric indicator completely within hours. Finally, unlike other functional groups, such as carbonates, that are used to connect alcohol-bearing molecules to controlled-release reagents, the linkage described in this article increases in hydrolytic stability (rather than decreases) as the pKa of the pendant alcohol decreases (Figure presented).

A two-component small molecule system for activity-based detection and signal amplification: Application to the visual detection of threshold levels of Pd(II)

A detection and signal amplification strategy aimed toward threshold diagnostic assays for use in resource-limited settings is described. The strategy employs two small molecule reagents that work in tandem. One reagent detects a specific analyte, while the second amplifies a colorimetric readout autocatalytically. The strategy is demonstrated using palladium(II) as a model analyte.