1286747-85-0

Upstream product

• 766-97-2 4-n-methylphenylacetylene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 189008-33-1 2-[2-(4-methylphenyl)ethynyl]benzaldehyde 

Downstream Products

• 1313495-80-5 4-bromo-N-cyclohexyl-3-p-tolylisoquinolin-1-amine 
• 1313495-81-6 4-bromo-N-isopropyl-3-p-tolylisoquinolin-1-amine 
• 67237-87-0 3-(4-methylphenyl)isoquinoline 
• 1450986-72-7 C₃₂H₂₄N₂O 
• 1589566-17-5 (Z)-1-(1-(3-benzylidene-1,3-dihydroisobenzofuran-1-yl)cyclopropyl)-3-p-tolylisoquinoline 

Relevant academic research and scientific papers

A metal-free tandem dehydrogenative α-arylation reaction of propargylic alcohols with 2-alkynylbenzaldoximes toward the synthesis of α-(4-bromo-isoquinolin-1-yl)-propenone skeletons

A tandem reaction of 2-alkynylbenzaldoximes with propargylic alcohols has been developed for the synthesis of α-(4-bromo-isoquinolin-1-yl)-propenones. Employing 2-alkynylbenzaldoximes as a precursor in the presence of Br2 generates 4-bromo-isoquinoline-N-

Synthesis of N-(isoquinolin-1-yl)sulfonamides via Ag2O-catalyzed tandem reaction of ortho-alkynylbenzaldoximes with benchtop stabilized ketenimines

In this project, a moderately efficient approach to multisubstituted N-(isoquinolin-1-yl)sulfonamide derivatives was illustrated, utilizing ortho-alkynylbenzaldoximes and zwitterionic ketenimine salts in a tandem reaction catalyzed by silver oxide. The oxophilicity of Ag2O, along with its nature as Lewis acid, pave the way for a smooth [3 + 2] cycloaddition between isoquinoline N-oxides and ketenimine species, which is a key step in this reaction. DFT calculation suggests that 1,3-dipolar cycloaddition of nitrone and ketenimine proceeds through a selective stepwise mechanism.

Efficient synthesis of isoquinoline derivatives via AgOTf/Cu(OTf) 2-cocatalyzed cyclization of 2-alkynyl benzaldoxime

An efficient, AgOTf and Cu(OTf)2 multicatalytic intramolecular cycloisomerization of 2-alkynylbenzaldoxime is reported. Isoquinoline N-oxides have been found to be deoxygenated to the corresponding quinolines in good yields in dimethylformamide/ dichloroethane (v/v 5:1) as solvent at 120 °C. Copyright Taylor & Francis Group, LLC.