1286763-64-1

Basic information

• Product Name: (2-methylbutyl)(4-methylphenyl)sulfane
• Synonyms: (2-methylbutyl)(4-methylphenyl)sulfane
• CAS NO: 1286763-64-1
• Molecular Weight: 194.341
• Mol File: 1286763-64-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2-methylbutyl)(4-methylphenyl)sulfane(CAS DataBase Reference)
• NIST Chemistry Reference: (2-methylbutyl)(4-methylphenyl)sulfane(1286763-64-1)
• EPA Substance Registry System: (2-methylbutyl)(4-methylphenyl)sulfane(1286763-64-1)

Safety Data

• Hazardous Substances Data: 1286763-64-1(Hazardous Substances Data)

Upstream product

• 20089-07-0 2-methyl-1-butanethiol 
• 624-31-7 4-tolyl iodide 
• 5720-05-8 4-methylphenylboronic acid 
• 130900-96-8 C₅H₁₁ClS 
• 4294-57-9 para-methylphenylmagnesium bromide 

Relevant articles and documents

Synthesis of aryl thioethers through the N -chlorosuccinimide-promoted cross-coupling reaction of thiols with Grignard reagents

A convenient one-pot approach for the synthesis of aryl sulfides through the coupling of thiols with Grignard reagents in the presence of N-chlorosuccinimide is described. The sulfenylchlorides were formed when thiols were treated with N-chlorosuccinimide, and the resulting sulfenylchlorides were then directly reacted with Grignard reagents to provide aryl sulfides in good to excellent yields under mild reaction conditions. Functional groups including ester, fluoro, and chloro are tolerated by the reaction conditions employed. It is important to note that this method has a short reaction time (30 min in total) and represents an alternative approach for the synthesis of aryl sulfides over the existing protocols.

Microwave-Assisted Copper-Catalyzed Cross-Coupling Reaction of Thiols with Aryl Iodides in Water

Microwave-promoted C-S bond formation from thiols and aryl iodides in the presence of a copper catalyst is reported. A combination of copper(II) oxide and 1,10-phenanthroline catalyzes this reaction. A variety of aryl iodides react smoothly with thiols to provide the corresponding aryl sulfides in good to excellent yields. Notably, the reactions proceed in water with a short reaction time (30 minutes). This system shows broad functional-group tolerance; amino, chloro, bromo, acetyl, and nitro groups are unaffected by the reaction conditions.

An efficient copper-catalyzed cross-coupling reaction of thiols with aryl iodides

Commercially available Cu2O powder is a very reactive catalyst for the coupling of thiols to aryl iodides. A variety of functional groups including esters, unprotected amines, alcohols, and heterocycles tolerate the reaction conditions. Moreover, di-ortho-substituted aryl iodides with sterically demanding substrates were also coupled to give the desired aryl thioethers in good to excellent yields. Copyright