128691-93-0

Usage

Uses

Used in Pharmaceutical Industry:
Acetamide, 2,2,2-trifluoro-N-(4-methoxy-2-nitrophenyl)is used as a building block for the synthesis of various drugs and pharmaceutical intermediates. Its unique structure allows for the creation of new compounds with potential therapeutic properties.
Used in Agrochemical Industry:
Acetamide, 2,2,2-trifluoro-N-(4-methoxy-2-nitrophenyl)is used as a component in the development of agrochemicals, such as pesticides and herbicides. Its chemical properties contribute to the effectiveness of these products in controlling pests and weeds.
Used in Dyes and Pigments Industry:
Acetamide, 2,2,2-trifluoro-N-(4-methoxy-2-nitrophenyl)is used as a raw material in the production of dyes and pigments. Its presence in these compounds can enhance their color properties and improve their stability.

Upstream product

• 332-34-3 2,2,2-trifluoro-N-(4-methoxy-phenyl)-acetamide 
• 104-94-9 4-methoxy-aniline 
• 407-25-0 trifluoroacetic anhydride 
• 96-96-8 4-methoxy-2-nitroaniline 

Downstream Products

• 128897-59-6 N-(2-amino-4-methoxyphenyl)-2,2,2-trifluoroacetoamide 
• 3360-79-0 N-methyl-4-methoxy-2-nitroaniline 
• 182058-27-1 2-(4-Chloro-phenyl)-1-methyl-1H-benzoimidazol-5-ol 
• 182061-08-1 N-(2-Amino-4-methoxy-phenyl)-4-chloro-N-methyl-benzamide 
• 182061-02-5 2-(4-Chloro-phenyl)-1-methyl-3-oxy-1H-benzoimidazol-5-ol 

Relevant academic research and scientific papers

Benzimidazole- and benzothiazole-quinones: Excellent substrates for NAD(P)H:quinone oxidoreductase 1

A series of benzimidazole- and benzothiazole-quinones has been synthesized. The ability of these heterocyclic quinones to act as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumour cells,

HUMAN CHYMASE INHIBITORS

The present invention provides a benzimidazole derivative or its pharmaceutically permissible salt expressed by the following formula (1). Further, the present invention provides a human chymase activity inhibitor containing the substance as an active ingredient. (the ring marked with A expresses a pyridine ring or a benzene ring; X1 and X2 are each a hydrogen atom, a halogen atom, a trihalomethyl group, a cyano group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, or the like; B is a substituted or unsubstituted alkylene group, or the like; E is -COOR4 or the like; G is a substituted or unsubstituted alkylene group; J is a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aryl group; and M is a sulfur atom, sulfoxide, sulfone or the like).

A 'one-pot' phase transfer alkylation/hydrolysis of o-nitrotrifluoroacetanilides. A convenient route to N-alkyl o-phenylenediamines

A variety of o-nitrotrifluoroacetanilides undergo a one-pot alkylation/hydrolysis to give N-alkyl o-nitroanilines in 40-94% yield. Dimethylsulfate, benzyl bromide and 1-bromo-propane were used as the electrophiles.

Synthesis of 1-Trifluoroacetyl-3-dialkylaminomethyl-5-monosubstituted Benzimidazoline-2-thiones using Trifluoroacetic Acid as an Acylating Agent

1-Trifluoroacetyl-3-dialkylaminomethyl-5-monosubstituted benzimidazoline-2-thiones have been synthesized from p-substituted anilines which were acetylated with trifluoroacetic acid.The trifluoroacetanilides were nitrated, reduced and cyclised with carbon