128702-12-5

Upstream product

• 14753-51-6 2,5-dibromohydroquinone 
• 6138-90-5 trans-geranyl bromide 
• 97088-24-9 1,4-dibromo-2,5-bis(methoxymethoxy)benzene 

Downstream Products

• 128702-14-7 (2R,4aR,9aR)-2,6-Dibromo-7-methoxymethoxy-1,1,4a-trimethyl-2,3,4,4a,9,9a-hexahydro-1H-xanthene 
• 128702-10-3 Cyclocymopol bismethoxymethyl ether 
• 62008-14-4 (E)-2-bromo-5-(3,7-dimethylocta-2,6-dien-1-yl)benzene-1,4-diol 
• 98437-54-8 1,3,5-tribromo-2-methoxymethoxybenzene 
• 118-79-6 2,4,6-tribromophenol 

Relevant academic research and scientific papers

Et2SBr.SbCl5Br: An effective reagent for direct bromonium-induced polyene cyclizations

It's all about reactivity: Although bromonium-induced cation-π cyclizations are commonly utilized by nature to fashion six-membered rings from a diverse set of polyene precursors, no general laboratory method exists that can achieve the same breadth of substrate scope. An easily synthesized and handled reagent is described (see scheme) that is capable of directly, broadly, and rapidly effecting such reactions in good yield with a variety of geraniol, farnesol, and nerol derivatives.

Synthesis of (+/-)-Cyclocymopol

The synthesis of (+/-)-Cyclocymopol (1) is descibed.Brominative cyclization with 2,4,4,6-tetrabromocyclohexadienone of cymopol bismethoxymethyl ether (7), which was obtained by monogeranylation of 2,5-dibromohydroquinone bismethoxymethyl ether (5), result