128717-77-1

Basic information

• Product Name: 7-METHOXY-1H-INDOLE-3-CARBOXYLIC ACID
• Synonyms: 7-METHOXY-1H-INDOLE-3-CARBOXYLIC ACID;7-METHOXYINDOLE-3-CARBOXYLIC ACID;1H-Indole-3-carboxylicacid, 7-Methoxy-;7-Methoxyindole-2-carboxylic acid
• CAS NO: 128717-77-1
• Molecular Formula: C10H9NO3
• Molecular Weight: 191.18
• Product Categories: Indoles and derivatives;Heterocycles series;Indoline & Oxindole
• Mol File: 128717-77-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 447.6 °C at 760 mmHg
• Flash Point: 224.5 °C
• Appearance: /
• Density: 1.381 g/cm³
• Vapor Pressure: 8.54E-09mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-METHOXY-1H-INDOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHOXY-1H-INDOLE-3-CARBOXYLIC ACID(128717-77-1)
• EPA Substance Registry System: 7-METHOXY-1H-INDOLE-3-CARBOXYLIC ACID(128717-77-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 128717-77-1(Hazardous Substances Data)

Usage

General Description

7-Methoxy-1H-indole-3-carboxylic acid is a chemical compound with the molecular formula C10H9NO3. It belongs to the class of organic compounds known as indolecarboxylic acids. 7-METHOXY-1H-INDOLE-3-CARBOXYLIC ACID is a derivative of indole, a heterocyclic aromatic compound. The presence of a methoxy group at the 7 position of the indole ring and a carboxylic acid group at the 3 position makes it a potentially important intermediate in the synthesis of various pharmaceuticals and organic compounds. It has the potential to be used in the development of new drugs and can also serve as a valuable tool in organic chemistry research.

InChI:InChI=1/C10H9NO3/c1-14-8-4-2-3-6-7(10(12)13)5-11-9(6)8/h2-5,11H,1H3,(H,12,13)

Upstream product

• 128717-76-0 7-methoxy-3-[(trifluoromethyl)carbonyl]-1H-indole 

Downstream Products

• 128717-78-2 C₁₀H₈ClNO₂ 
• 582319-20-8 methyl 7-methoxy-1H-indole-3-carboxylate 

Relevant articles and documents

(INDOL-3-YL)-HETEROCYCLE DERIVATIVES AS AGONISTS OF THE CANNABINOID CB1 RECEPTOR

The invention relates to (indol-3-yl)-heterocycle derivatives having general Formula (I) wherein A represents a 5-membered aromatic heterocyclic ring, wherein X1, X2 and X3 are independently selected from N, O, S and CR; R is H or (C1-4)alkyl; or R, when present in X2 or X3, may form together with R3 a 5-8 membered ring; R1 is a 5-8 mem-bered saturated carbocyclic ring, optionally containing a heteroatom selected from O and S; R2 is H, CH3 or CH2-CH3;or R2 is joined together with R7 to form a 6-mem-bered ring, optionally containing a heteroatom selected from O and S, and which heteroatom is bonded to the 7-position of the indole ring; R3 and R4 are independent-ly H, (C1-6)alkyl or (C3-7)cycloalkyl, the alkyl groups being optionally substituted with OH, (C1-4)alkyloxy, (C1-4)alkylthio, (C1-4)alkylsulfonyl, CN or halogen; or R3 together with R4 and the N to which they are bonded form a 4-8 membered ring optionally containing a further heteroatom selected from O and S, and which is optionally sub-stituted with OH, (C1-4)alkyl, (C1-4)alkyloxy, (C1-4)alkyloxy- (C1-4)alkyl, or halogen; or R3 together with R5 forms a 4-8 membered ring optionally containing a further hetero-atom selected from O and S, and which is optionally substituted with OH, (C1-4)alkyl, (C1-4)alkyloxy, (C1-4)alkyloxy- (C1-4)alkyl, or halogen; or R3 together with R, when present in X2 or X3, forms a 5-8 membered ring; R5 is H or (C1-4)alkyl; or R5 together with R3 forms a 4-8 membered ring optionally containing a further heteroatom select-ed from O and S, and which is optionally substituted with OH, (C1-4)alkyl, (C1-4)alkyl-oxy, (C1-4) alkyloxy- (C1-4)alkyl, or halogen; R5' is H or (C1-4)alkyl; R6 represents 1-3 substituents independently selected from H, (C1-4 alkyl, (C1-4) alkyloxy, CN and halogen; R7 is H, (C1-4)alkyl, (C1-4)alkyloxy, CN or halogen; or R7 is joined together with R2 to form a 6-membered ring, optionally containing a further heteroatom selected from O and S, and which heteroatom is bonded to the 7-position of the indole ring; or a pharmaceutically acceptable salt thereof, as agonists of the cannabinoid CB1 receptor, which can be used in the treatment of pain such as for example peri-operative pain, chronic pain, neuropathic pain, cancer pain and pain and spasticity associated with multiple sclerosis.

Organic nitriles as insect antifeedants

Members of a novel class of organic nitriles related to an indole alkoaloid of Dithyrea wislizenii (Cruciferae) have been discovered to be potent feeding inhibitors of the fall armyworm and European corn borer.