128720-08-1

Upstream product

• 90-02-8 salicylaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 15119-34-3 3-cyanocoumarin 
• 1846-76-0 ethyl coumarin-3-carboxylate 

Relevant academic research and scientific papers

A functionalized UiO-66 MOF for turn-on fluorescence sensing of superoxide in water and efficient catalysis for Knoevenagel condensation

In the present work, a new MOF material of the UiO-family called Zr-UiO-66-NH-CH2-Py (1) has been obtained by the solvothermal technique and successfully characterized. The MOF structure was assembled with 2-((pyridin-4-ylmethyl) amino) terephthalic acid (H2BDC-NH-CH2-Py) as linker and Zr4+ ion. The activated form of 1 (called 1′) exhibits considerable thermal and chemical stability. Compound 1′ showed a very rapid and selective response for the fluorometric sensing of superoxide (O2·-) in aqueous medium even in the presence of the potentially competitive reactive oxygen species (ROS). The limit of detection value for O2·- sensing is 0.21 μM, which is comparable with those of the reported O2·- sensors. This is the first MOF based fluorescent sensor for the detection of O2·-. The response time of this MOF sensor for O2·- is very short (240 s). On the other hand, 1′ was employed as a solid heterogeneous catalyst for Knoevenagel condensation between benzaldehyde and ethyl cyanoacetate at 80 °C in ethanol resulting in a very high yield of the desired product. The effects of the esterified linker ((CH3)2BDC-NH-CH2-Py) and the corresponding metal salt (ZrCl4) on this catalytic reaction were examined separately. We have also tested the substrate scope elaborately for the catalytic reaction promoted by catalyst 1′.

First example of organocatalysis by polystyrene-supported PAMAM dendrimers: Highly efficient and reusable catalyst for knoevenagel condensations

This paper describes the first use of polystyrene-supported poly(amidoamine) (PAMAM) dendrimers as heterogeneous basic organocatalysts for carbon-carbon bond formation. Polystyrene-supported PAMAM dendrimers of first, second and third generations have been used as reusable base catalysts in Knoevenagel condensations of carbonyl compounds with active methylene compounds. The reactions proceed in short periods of time and with 100% selectivity. This novel catalyst eliminates the use of aromatic and halogenated solvents, as well as complex purification processes. The catalysts can be recycled ten times. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

Condensation of ethyl cyanoacetate with aromatic aldehydes in water, catalyzed by morpholine

Synthesis of (E)-ethyl 2-cyano-3-phenylacrilate derivatives in water catalyzed by morpholine was investigated. The reactions were performed under green chemistry conditions. Copyright

Fully-occupied Keggin type polyoxometalate as solid base for catalyzing CO2 cycloaddition and Knoevenagel condensation

The highly negatively charged alkaline Keggin type polyoxometalate (POM) Na16[SiNb12O40]·xH2O (NaSiNb12) was synthesized and used as an efficient solid base catalyst for CO2 cycloaddition a

Aminated poly(vinyl chloride): An efficient green catalyst for Knoevenagel condensation reactions

Commercially available poly(vinyl chloride) have been modified with ethylene diamine to give a highly efficient reusable organocatalyst for Knoevenagel condensation in water as well as under solvent-less conditions. The reaction proceeds with high yield a

Controllable acid-base bifunctionalized mesoporous silica: Highly efficient catalyst for solvent-free Knoevenagel condensation reaction

A controllable acid-base bifunctionalized mesoporous catalyst with acidic sites and basic sites in adjacent arrangements was prepared via an in situ cleavage of sulfonamide bond on synthetic process. During Knoevenagel condensation reaction of aromatic al

An eco-friendly synthesis of electrophilic alkenes catalyzed by dimethylaminopyridine under solvent-free conditions

Electrophilic olefins were synthesized in solvent-free condition using DMAP (10%mol) as catalyst in excellent yield and E-geometry. The various aldehydes which are aliphatic, aromatic, and heterocyclics underwent smoothly for Knoevenagel condensation with

Phosphane-Catalyzed Knoevenagel Condensation: A Facile Synthesis of α-Cyanoacrylates and α-Cyanoacrylonitriles

Triphenylphosphane (TPP) has been utilized as a novel and efficient catalyst for the Knoevenagel condensation of aldehydes with acidic methylene compounds such as ethyl cyanoacetate and malononitrile to afford substituted olefins. The reaction proceeds smoothly under mild and solvent-free conditions and the products are obtained in excellent yields with an E-geometry. This method is applicable for a wide range of aldehydes including aromatic, aliphatic and heterocyclic substrates. Microwave irradiation has been used to achieve enhanced reaction rates and improved yields. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

An efficient benzyltriethylammonium chloride catalysed preparation of electrophilic alkenes: a practical synthesis of trimethoprim

The Knoevenagel condensation of carbonyl compounds with active methylene compounds was readily carried out with benzyltriethylammonium chloride as a catalytic agent, under solvent-free conditions to produce olefinic products in high yeilds: the scope of this protocol is utilised for the synthesis of the antibacterial agent trimethoprim.