128721-29-9Relevant academic research and scientific papers
SYNTHESIS AND REACTIVITY OF 2-(1,3-DITHIAN-2-YL)INDOLES. III. INFLUENCE OF THE INDOLE PROTECTIVE N-PHENYLSULFONYL GROUP
Rubiralta, Mario,Diez, Anna,Reig, Ignasi,Castells, Josep,Bettiol, Jean-Luc,et al.
, p. 173 - 186 (2007/10/02)
Formation of the anion of 2-(1,3-dithian-2-yl)indoles was shown to be possible when the indole nitrogen is protected by a p-methoxyphenylsulfonyl group.In contrast to the corresponding N-phenylsulfonylindole dithiane 1, the anion of dithiane 2 reacts efficiently with electrophiles.The influence of the indole protective group on the metallation of 2-bis(ethylthio)-methyl-1-(phenylsulfonyl)indole (14) and the corresponding sulfoxide 24 with n-butyllithium is also reported.
