1287225-55-1Relevant academic research and scientific papers
Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease
Trapero, Ana,González-Bulnes, Patricia,Butters, Terry D.,Llebaria, Amadeu
supporting information; experimental part, p. 4479 - 4488 (2012/08/14)
Amino-myo-inositol derivatives have been found to be potent inhibitors of glucocerebrosidase (GCase), the β-glucosidase enzyme deficient in Gaucher disease (GD). When tested using lymphoblasts derived from patients with GD homozygous for N370S or L444P mu
Polyhydroxylated bicyclic isoureas and guanidines are potent glucocerebrosidase inhibitors and nanomolar enzyme activity enhancers in gaucher cells
Trapero, Ana,Alfonso, Ignacio,Butters, Terry D.,Llebaria, Amadeu
supporting information; experimental part, p. 5474 - 5484 (2011/06/17)
Four diastereomeric series of N-alkylated [6+5] bicyclic isoureas having hydroxyl substituents mimicking glucose hydroxyl groups have been synthesized as potential β-glucocerebrosidase (GCase) inhibitors with the aim of developing pharmacological chaperon
