1287225-64-2Relevant academic research and scientific papers
Polyhydroxylated bicyclic isoureas and guanidines are potent glucocerebrosidase inhibitors and nanomolar enzyme activity enhancers in gaucher cells
Trapero, Ana,Alfonso, Ignacio,Butters, Terry D.,Llebaria, Amadeu
supporting information; experimental part, p. 5474 - 5484 (2011/06/17)
Four diastereomeric series of N-alkylated [6+5] bicyclic isoureas having hydroxyl substituents mimicking glucose hydroxyl groups have been synthesized as potential β-glucocerebrosidase (GCase) inhibitors with the aim of developing pharmacological chaperon
