1287227-02-4Relevant articles and documents
Polyhydroxylated bicyclic isoureas and guanidines are potent glucocerebrosidase inhibitors and nanomolar enzyme activity enhancers in gaucher cells
Trapero, Ana,Alfonso, Ignacio,Butters, Terry D.,Llebaria, Amadeu
supporting information; experimental part, p. 5474 - 5484 (2011/06/17)
Four diastereomeric series of N-alkylated [6+5] bicyclic isoureas having hydroxyl substituents mimicking glucose hydroxyl groups have been synthesized as potential β-glucocerebrosidase (GCase) inhibitors with the aim of developing pharmacological chaperon