1287660-82-5

Basic information

• Product Name: 1-bromo-2-[2-(prop-2-yn-1-yloxy)ethoxy]ethane
• CAS NO: 1287660-82-5
• Molecular Weight: 207.067
• Mol File: 1287660-82-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-bromo-2-[2-(prop-2-yn-1-yloxy)ethoxy]ethane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-[2-(prop-2-yn-1-yloxy)ethoxy]ethane(1287660-82-5)
• EPA Substance Registry System: 1-bromo-2-[2-(prop-2-yn-1-yloxy)ethoxy]ethane(1287660-82-5)

Safety Data

• Hazardous Substances Data: 1287660-82-5(Hazardous Substances Data)

Usage

Physical state

Clear, colorless liquid

Molecular weight

209.07 g/mol

Usage

Organic synthesis as a reagent and intermediate for the preparation of various other chemicals

Health and environmental impact

Potential hazardous effects on human health and the environment, should be handled with care

Bromine atom

Attached to a two-carbon chain

Ether linkages

Two present in the structure

Terminal group

Alkyne group, making it a versatile building block for various chemical reactions

Upstream product

• 7218-43-1 2-(2-(prop-2-ynyloxy)ethoxy)ethanol 

Relevant articles and documents

Molecular Engineering of Trifunctional Supported Catalysts for the Aerobic Oxidation of Alcohols

We describe a simple and general method for the preparation and molecular engineering of supported trifunctional catalysts and their application in the representative Cu/TEMPO/NMI-catalyzed aerobic oxidation of benzyl alcohol. The methodology allows in one single step to immobilize, with precise control of surface composition, both pyta, CuI, TEMPO, and NMI sites on azide-functionalized silica particles. To optimize the performance of the heterogeneous trifunctional catalysts, synergistic interactions are finely engineered through modulating the degree of freedom of the imidazole site as well as tuning the relative surface composition, leading to catalysts with an activity significantly superior to the corresponding homogeneous catalytic system.

Synthetic antibody protein mimics of infliximab by molecular scaffolding on novel CycloTriVeratrilene (CTV) derivatives

Syntheses of novel semi-orthogonally protected CycloTriVeratrilene (CTV) analogues with enhanced water solubility, that is 3 and 4, derived from the previously described CTV scaffold derivative 2 are described here. These scaffolds 2-4 enabled a sequential introduction of three different complementarity determining region (CDR) mimics via Cu(i)-catalysed azide-alkyne cycloaddition towards medium-sized protein mimics denoted as "synthetic antibodies". The highly optimised sequential introduction enabled selective attachment of three different CDR mimics in a one-pot fashion. This approach of obtaining synthetic antibodies, demonstrated by the synthesis of paratope mimics of monoclonal antibody infliximab (Remicade), provided a facile access to a range of (highly) pre-organised molecules bearing three different (cyclic) peptide segments and may find a wide range of applications in the field of protein-protein interaction disruptors as well as in the development of synthetic vaccines or lectin mimics. The prepared synthetic antibodies were tested for their affinity towards tumour necrosis factor alpha using surface plasmon resonance and synthetic antibodies with micromolar affinities were uncovered.