1287677-50-2Relevant academic research and scientific papers
Structure-activity relationship studies of sphingosine-1-phosphate receptor agonists with N-cinnamyl-β-alanine moiety
Kurata, Haruto,Otsuki, Kazuhiro,Kusumi, Kensuke,Kurono, Masakuni,Terakado, Masahiko,Seko, Takuya,Mizuno, Hirotaka,Ono, Takeji,Hagiya, Hiroshi,Minami, Masashi,Nakade, Shinji,Habashita, Hiromu
scheme or table, p. 1390 - 1393 (2011/04/16)
Structure-activity relationship of sphingosine-1-phosphate receptor agonist was examined. In terms of reducing the flexibility of molecule, hit compound 1 was modified to improve S1P1 agonistic activity as well as selectivity over S1P3 agonistic activity. Novel S1P agonists with cinnamyl scaffold or 1,2,5,6-tetrahydropyridine scaffold were identified.
