1287681-07-5Relevant academic research and scientific papers
Paraminabeolides A-F, cytotoxic and anti-inflammatory marine withanolides from the soft coral Paraminabea acronocephala
Chao, Chih-Hua,Chou, Kuei-Ju,Wen, Zhi-Hong,Wang, Guey-Horng,Wu, Yang-Chang,Dai, Chang-Feng,Sheu, Jyh-Horng
experimental part, p. 1132 - 1141 (2011/07/08)
(Chemical Equation Presented) Six new withanolides, paraminabeolides A-F (1-6), along with five known compounds, minabeolides-1, -2, -4, -5, and -8 (7-11), were isolated from a Formosan soft coral, Paraminabea acronocephala. The structures of these compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The absolute configuration of 4 was determined by the application of Mosher's method. Compounds 1 and 7 were cytotoxic toward Hep G2 cancer cells. Compounds 1-4 and 7-10 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein. Compounds 7-10 also could effectively reduce the expression of COX-2 protein.
