1287708-98-8

Basic information

• Product Name: (10R)-N-{4-[3-(2,4-difluorophenyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin
• Synonyms: (10R)-N-{4-[3-(2,4-difluorophenyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin
• CAS NO: 1287708-98-8
• Molecular Weight: 583.629
• Mol File: 1287708-98-8.mol

Chemical Properties

• CAS DataBase Reference: (10R)-N-{4-[3-(2,4-difluorophenyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin(CAS DataBase Reference)
• NIST Chemistry Reference: (10R)-N-{4-[3-(2,4-difluorophenyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin(1287708-98-8)
• EPA Substance Registry System: (10R)-N-{4-[3-(2,4-difluorophenyl)-2-(E)-propenoyl]phenyloxyacetyl}aminodihydroartemisinin(1287708-98-8)

Safety Data

• Hazardous Substances Data: 1287708-98-8(Hazardous Substances Data)

Upstream product

• 99-93-4 4-Hydroxyacetophenone 
• 81496-81-3 dihydroartesiminin 
• 1550-35-2 2,4-difluorobenzaldehyde 
• 1287709-16-3 10α-aminodihydroartemisinin 
• 1119668-68-6 10-α-azidodihydroartemisinin 
• 1287709-17-4 (10R)-N-chloroacetyl-aminodihydroartemisinin 

Relevant articles and documents

Design, synthesis and antitumor activity of novel artemisinin derivatives using hybrid approach

In an attempt to develop potent and selective anti-tumor agents, two novel series of artemisinin-chalcone hybrids were designed, synthesized and screened for their antitumor activities against HT-29, A549, MDA-MB-231, HeLa and H460 cell lines in vitro. Nearly all of the tested compounds showed significantly increased anti-tumor activity compared with the corresponding dihydroartemisinin (DHA). Most of the title compounds displayed good selectivity toward HT-29 and HeLa cell lines with IC50 values ranging from 0.09 to 0.85μM. Among them, the most promising compound 9c (IC50 range of 0.09-0.93μM) was 10.5- to 70-times more active than DHA (IC50 range of 5.6-15.6μM) respectively.