1287715-00-7Relevant academic research and scientific papers
Organic doping material for memory device, nonvolatile memory device including the same and method of manufacturing the same
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Paragraph 0069; 0072, (2017/01/02)
Provided are an organic doping material for memory devices, a nonvolatile memory device comprising the organic doping material, and a method of manufacturing the nonvolatile memory device. According to the present invention, if the organic doping material
Synthesis and evaluation of thioflavin-T analogs as potential imaging agents for amyloid plaques
Jung, Soon Jae,Park, Yong Dae,Park, Jeong Hoon,Yang, Seung Dae,Hur, Min Goo,Yu, Kook Hyun
, p. 4263 - 4268 (2013/09/02)
Thioflavin-T (ThT) is a benzothiazole dye that exhibits enhanced fluorescence upon binding to beta-amyloid (Aβ) plaques and is commonly used in the diagnosis of Alzheimer's disease (AD). In this study, the ThT analogs were designed and synthesized, and screening was conducted for the detection of Aβ 40 fibrils in vitro. Among these compounds, 2-(2′-methoxy-4′-methylaminophenyl)benzoxazole (2) meets two critical requirements for an imaging agent: high its higher fluorescent responsiveness and stronger binding affinity than those of ThT. This compound showed the highest binding affinity with a dissociation constant of 3.27 ± 0.29 μM, and selectively stained Aβ aggregated in SHSY5Y neuroblastoma cells. This finding demonstrates the compound's potential use as a brain-imaging agent for AD studies. Graphical abstract: [Figure not available: see fulltext.]
