1287745-42-9

Basic information

• Product Name: C₃₃H₃₈N₂O₆
• Synonyms: C₃₃H₃₈N₂O₆
• CAS NO: 1287745-42-9
• Molecular Weight: 558.675
• Mol File: 1287745-42-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₃₃H₃₈N₂O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₃₈N₂O₆(1287745-42-9)
• EPA Substance Registry System: C₃₃H₃₈N₂O₆(1287745-42-9)

Safety Data

• Hazardous Substances Data: 1287745-42-9(Hazardous Substances Data)

Upstream product

• 1738-68-7 Gly-OBz 
• 206759-97-9 5-tert-butyl 1-oxo-2(S)-<(9-fluorenylmethoxycarbonyl)amino>caproate 
• 2462-31-9 benzyl 2-aminoacetate hydrochloride 

Downstream Products

• 1287745-60-1 C₄₂H₄₆N₂O₇ 
• 1287745-87-2 C₃₅H₄₀N₂O₇ 

Relevant articles and documents

Β?CATENIN/ B-CELL LYMPHOMA 9 PROTEIN?PROTEIN INTERACTION INHIBITING PEPTIDOMIMETICS

Disclosed herein is a series of helical sulfono-γ-AApeptides that mimic the binding mode of the α-helical HD2 domain of B-Cell Lymphoma 9 (BCL9). As disclosed herein, sulfono-γ-AApeptides can structurally and functionally mimic the α-helical domain of BCL9, and selectively disrupt β?catenin/BCL9 PPIs with even higher potency. More intriguingly, these sulfono-γ-AApeptides can enter cancer cells, bind with β?catenin and disrupt β?catenin/BCL PPI, and exhibit excellent cellular activity, which is much more potent than the BCL9 peptide. Furthermore, enzymatic stability studies demonstrated the remarkable stability of the helical sulfono-γ-AApeptides, with no degradation in the presence of pronase for 24 h, augmenting their biological potential.

γ-AApeptides: Design, synthesis and evaluation

A new class of peptide mimics termed "γ-AApeptides" has been described. The design and synthesis of γ-AApeptides, and potential bioactivities towards p53/MDM2 interaction were demonstrated. γ-AApeptides were also found to be highly resistant to proteolysis. The development of sequence-specific γ-AApeptides may lead to a family of peptidomimetics with a new framework for drug discovery or peptide/protein mimicry.