128776-27-2

Upstream product

• 18742-02-4 2-bromo-2-(2-ethyl)dioxolane 
• 140-29-4 phenylacetonitrile 
• 4553-07-5 ethyl phenylcyanoacetate 

Downstream Products

• 128776-32-9 2-Phenyl-5,5-ethylenedioxypentaneamide 
• 112845-48-4 4-Cyano-4-<2-(1,3-dioxolanyl)-ethyl>-4-phenyl-buttersaeuremethylester 
• 128801-22-9 3-Phenyl-3,4-dihydro-2(1H)-pyridinone 
• 112838-61-6 4-Cyano-4-<2-(1,3-dioxolanyl)-ethyl>-4-phenyl-buttersaeure 

Relevant academic research and scientific papers

NITROGENOUS CYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

The present invention provides a novel compound having a superior calcium antagonism, in particular, a neuron-selective calcium antagonism. Namely, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, Ar indicates an optionally substituted 5- to 14-membered aromatic ring etc.; the ring A indicates any one ring selected from a piperazine, a homopiperazine, a piperidine and the like; the ring B indicates an optionally substituted C3-14 hydrocarbon ring etc.; E indicates a single bond, a group represented by the formula -CO-, etc.; X indicates a single bond, an oxygen atom etc.; R1 indicates a hydrogen atom, a halogen atom, a hydroxyl group etc.; and D1, D2, W1 and W2 are the same as or different from each other and each represents a single bond or an optionally substituted C1-6 alkylene chain.

Synthesis of 3-Substituted-3,4-dihydro-2(1H)-pyridinones from Nitriles

A number of the title compounds have been prepared through a three step reaction based on the cyclization of δ-acetal amides.