1287769-56-5Relevant academic research and scientific papers
Benzannulation for the regiodefined synthesis of 2-alkyl/aryl-1-naphthols: Total synthesis of arnottin i
Mal, Dipakranjan,Jana, Amit Kumar,Mitra, Prithiba,Ghosh, Ketaki
, p. 3392 - 3398 (2011)
The annulation of phthalides with α-alkyl/arylacrylates in the presence of LDA/LHMDS is shown to directly give alkyl/aryl-1-naphthols. The method involving a novel dealkoxycarbonylation obviates the regiochemical issues in the synthesis of polysubstituted naphthalenes, and it forms the key step in a three-step total synthesis of arnottin I, a naphthobenzopyranone natural product.
