1287777-05-2

Basic information

• Product Name: 3-(Tetrahydropyran-2-yloxy)phenylboronic acid
• Synonyms: 3-THPO-phenylboronic acid
• CAS NO: 1287777-05-2
• Molecular Formula: C₁₁H₁₅BO₄
• Molecular Weight: 222.0454
• Mol File: 1287777-05-2.mol

Chemical Properties

• Boiling Point: 420.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.97±0.10(Predicted)
• CAS DataBase Reference: 3-(Tetrahydropyran-2-yloxy)phenylboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Tetrahydropyran-2-yloxy)phenylboronic acid(1287777-05-2)
• EPA Substance Registry System: 3-(Tetrahydropyran-2-yloxy)phenylboronic acid(1287777-05-2)

Safety Data

• Hazardous Substances Data: 1287777-05-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
3-(Tetrahydropyran-2-yloxy)phenylboronic acid is utilized as a reagent in the Suzuki-Miyaura coupling reaction, a pivotal method for the creation of carbon-carbon bonds. This reaction is instrumental in constructing complex organic molecules and plays a significant role in the synthesis of various compounds.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 3-(Tetrahydropyran-2-yloxy)phenylboronic acid is employed as a key intermediate in the preparation of a range of pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Production:
3-(Tetrahydropyran-2-yloxy)phenylboronic acid also finds application in the agrochemical sector, where it is used in the synthesis of various agrochemicals. Its role in this industry is crucial for the development of effective crop protection agents and other agricultural products.
Used in Material Science:
3-(Tetrahydropyran-2-yloxy)phenylboronic acid contributes to the advancement of material science by being a component in the synthesis of new materials with specific properties required for various applications.
Used in Cancer Research and Treatment:
3-(Tetrahydropyran-2-yloxy)phenylboronic acid has demonstrated potential anti-cancer activities, making it a valuable compound for research and development in oncology. Its exploration in this field could lead to the discovery of new cancer therapeutics.
Used in Inflammation and Anti-Inflammatory Research:
3-(Tetrahydropyran-2-yloxy)phenylboronic acid's potential anti-inflammatory properties position it as a candidate for research into treatments for inflammatory conditions, offering new avenues for managing such diseases.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 57999-49-2 3-(tetrahydropyran-2-yloxy)phenyl bromide 
• 591-20-8 3-Bromophenol 

Downstream Products

• 1287777-08-5 (3'-fluorobiphenyl-3,4'-diyloxy)bis(tetrahydro-2H-pyran) 
• 1287777-09-6 (3'-chlorobiphenyl-3,4'-diyloxy)bis(tetrahydro-2H-pyran) 
• 1287777-13-2 3,4'-bis(4-nitrobenzoyloxy)-3'-fluorobiphenyl 
• 1287777-14-3 3,4'-bis(4-nitrobenzoyloxy)-3'-chlorobiphenyl 
• 1287777-16-5 3,4'-bis(4-aminobenzoyloxy)-3'-fluorobiphenyl 
• 1287777-17-6 3,4'-bis(4-aminobenzoyloxy)-3'-chlorobiphenyl 
• 1287777-19-8 3'-fluorobiphenyl-3,4'-diyl bis[4-(2-hydroxy-4-(tetradecyloxy)benzylideneamino)benzoate] 
• 1287777-20-1 3'-chlorobiphenyl-3,4'-diyl bis[4-(2-hydroxy-4-(tetradecyloxy)benzylideneamino)benzoate] 
• 1287777-07-4 (biphenyl-3,4'-diyloxy)bis(tetrahydro-2H-pyran) 
• 1198802-79-7 4-nitro-2-(tetrahydro-2H-pyran-2-yl)-6-[3-(tetrahydro-2H-pyran-2-yloxy)phenyl]-2H-indazole 

Relevant articles and documents

Synthesis and characterization of achiral bent-core liquid crystalline molecules containing salicylaldimine-based with a wide temperature range of SmCP phase

The design and synthesis of a series bent-core materials base on a 3,4'-biphenyldiol central core containing salicylaldimine-based and two terminal tetradecyloxy tails are reported. In addition, the effects of lateral substituents (R = F and Cl) at the biphenyl core into 3'-position are examined. These substituents have a strong influence in reducing the clearing temperatures and increasing temperature range of SmCP phase. Upon cooling process the isotropic liquid, compound SB-Cl exhibits the lowest clearing transition temperature of 180 oC and the widest SmCP phase range of 129 °C. The mesophase behaviour were investigated by polarizing optical microscopy (POM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and electro-optical (EO) measurements in the mesophase temperature range.