1287777-06-3

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 3964-56-5 4-bromo-2-chlorophenol 

Downstream Products

• 1287777-14-3 3,4'-bis(4-nitrobenzoyloxy)-3'-chlorobiphenyl 
• 1287777-17-6 3,4'-bis(4-aminobenzoyloxy)-3'-chlorobiphenyl 
• 1287777-20-1 3'-chlorobiphenyl-3,4'-diyl bis[4-(2-hydroxy-4-(tetradecyloxy)benzylideneamino)benzoate] 
• 1287777-09-6 (3'-chlorobiphenyl-3,4'-diyloxy)bis(tetrahydro-2H-pyran) 

Relevant academic research and scientific papers

N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and compounds I for use to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).

Synthesis and characterization of achiral bent-core liquid crystalline molecules containing salicylaldimine-based with a wide temperature range of SmCP phase

The design and synthesis of a series bent-core materials base on a 3,4'-biphenyldiol central core containing salicylaldimine-based and two terminal tetradecyloxy tails are reported. In addition, the effects of lateral substituents (R = F and Cl) at the biphenyl core into 3'-position are examined. These substituents have a strong influence in reducing the clearing temperatures and increasing temperature range of SmCP phase. Upon cooling process the isotropic liquid, compound SB-Cl exhibits the lowest clearing transition temperature of 180 oC and the widest SmCP phase range of 129 °C. The mesophase behaviour were investigated by polarizing optical microscopy (POM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and electro-optical (EO) measurements in the mesophase temperature range.