1287777-06-3Relevant articles and documents
N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
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Paragraph 000344, (2015/05/19)
Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and compounds I for use to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
Synthesis and characterization of achiral bent-core liquid crystalline molecules containing salicylaldimine-based with a wide temperature range of SmCP phase
Liao, Chien-Tung,Liu, Jung-Yo,Zou, Sing-Fang,Wu, Nien-Chieh,Wu, Zheng-Long,Lee, Jiunn-Yih
scheme or table, p. 124 - 133 (2011/04/15)
The design and synthesis of a series bent-core materials base on a 3,4'-biphenyldiol central core containing salicylaldimine-based and two terminal tetradecyloxy tails are reported. In addition, the effects of lateral substituents (R = F and Cl) at the biphenyl core into 3'-position are examined. These substituents have a strong influence in reducing the clearing temperatures and increasing temperature range of SmCP phase. Upon cooling process the isotropic liquid, compound SB-Cl exhibits the lowest clearing transition temperature of 180 oC and the widest SmCP phase range of 129 °C. The mesophase behaviour were investigated by polarizing optical microscopy (POM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and electro-optical (EO) measurements in the mesophase temperature range.