1287795-36-1Relevant academic research and scientific papers
Asymmetric organocatalytic tandem cyclization/transfer hydrogenation: A synthetic strategy for enantioenriched nitrogen heterocycles
Shi, Feng,Tan, Wei,Zhang, Hong-Hao,Li, Mei,Ye, Qin,Ma, Guan-Hua,Tu, Shu-Jiang,Li, Guigen
, p. 3715 - 3726 (2014/01/06)
An asymmetric organocatalytic tandem reaction comprising cyclization/transfer hydrogenation has been established in a compatible and synergistic way, leading to the step-economical synthesis of enantioenriched tetrahydroquinoxalines and dihydroquinoxalinones from readily accessible materials in excellent enantioselectivity of up to >99% ee. This protocol of a one-operation tandem reaction combines the merits of both tandem reactions and asymmetric organocatalysis, providing an efficient strategy for concisely and enantioselectively synthesizing nitrogen heterocycles with biological relevance. Copyright
Cooperative iron-bronsted acid catalysis: Enantioselective hydrogenation of quinoxalines and 2h-1,4-benzoxazines
Fleischer, Steffen,Zhou, Shaolin,Werkmeister, Svenja,Junge, Kathrin,Beller, Matthias
supporting information, p. 4997 - 5003 (2013/06/26)
The financial support from the state of Mecklenburg-Vorpommern and the Bundesministerium fur Bildung und Forschung (BMBF) is gratefully acknowledged. S.F. is thankful for the financial support of the Evonik Stiftung. We thank Dr. W. Baumann, Dr. C. Fische
Dihydrophenanthridine: A new and easily regenerable NAD(P)H model for biomimetic asymmetric hydrogenation
Chen, Qing-An,Gao, Kai,Duan, Ying,Ye, Zhi-Shi,Shi, Lei,Yang, Yan,Zhou, Yong-Gui
supporting information; experimental part, p. 2442 - 2448 (2012/03/10)
A new and easily regenerable NAD(P)H model 9,10-dihydrophenanthridine (DHPD) has been designed for biomimetic asymmetric hydrogenation of imines and aromatic compounds. This reaction features the use of hydrogen gas as terminal reductant for the regenerat
General asymmetric hydrogenation of 2-alkyl- and 2-aryl-substituted quinoxaline derivatives catalyzed by iridium-difluorphos: Unusual halide effect and synthetic application
Cartigny, Damien,Berhal, Farouk,Nagano, Takuto,Phansavath, Phannarath,Ayad, Tahar,Genet, Jean-Pierre,Ohshima, Takashi,Mashima, Kazushi,Ratovelomanana-Vidal, Virginie
experimental part, p. 4544 - 4556 (2012/07/14)
A general asymmetric hydrogenation of a wide range of 2-alkyl- and 2-aryl-substituted quinoxaline derivatives catalyzed by an iridium-difluorphos complex has been developed. Under mild reaction conditions, the corresponding biologically relevant 2-substit
Convergent asymmetric disproportionation reactions: Metal/Bronsted acid relay catalysis for enantioselective reduction of quinoxalines
Chen, Qing-An,Wang, Duo-Sheng,Zhou, Yong-Gui,Duan, Ying,Fan, Hong-Jun,Yang, Yan,Zhang, Zhang
supporting information; experimental part, p. 6126 - 6129 (2011/06/22)
A convergent asymmetric disproportionation of dihydroquinoxalines for the synthesis of chiral tetrahydroquinoxalines using a metal/Bronsted acid relay catalysis system has been developed. The use of hydrogen gas as the reductant makes the convergent dispr
Iridium-difluorphos-catalyzed asymmetric hydrogenation of 2-alkyl- and 2-aryl-substituted quinoxalines: A general and efficient route into tetrahydroquinoxalines
Cartigny, Damien,Nagano, Takuto,Ayad, Tahar,Genet, Jean-Pierre,Ohshima, Takashi,Mashima, Kazushi,Ratovelomanana-Vidala, Virginie
supporting information; experimental part, p. 1886 - 1891 (2010/10/21)
A highly efficient and general iridium-difluorphos-catalyzed asymmetric hydrogenation of diverse 2-alkyl- and 2-aryl-substituted quinoxalines into biologically and pharmaceutically relevant 2-substituted-1,2,3,4- tetrahydroquinoxaline units has been developed. High isolated yields and excellent enantioselectivities of up to 95% for 2-alkyl-substituted quinoxalines and of up to 94% for 2-aryl-substituted quinoxalines were obtained.
