128781-34-0

Basic information

• Product Name: Piperidine, 1-(1-thioxoheptyl)- (9CI)
• Synonyms: Piperidine, 1-(1-thioxoheptyl)- (9CI)
• CAS NO: 128781-34-0
• Molecular Formula: C12H23NS
• Molecular Weight: 0
• Mol File: 128781-34-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperidine, 1-(1-thioxoheptyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-(1-thioxoheptyl)- (9CI)(128781-34-0)
• EPA Substance Registry System: Piperidine, 1-(1-thioxoheptyl)- (9CI)(128781-34-0)

Safety Data

• Hazardous Substances Data: 128781-34-0(Hazardous Substances Data)

Upstream product

• 18494-53-6 1-(piperidin-1-yl)heptan-1-one 
• 110-89-4 piperidine 
• 2528-61-2 Heptanoic acid chloride 

Relevant articles and documents

7-Oxabicycloheptyl Carboxylic Acids as Thromboxane A2 Antagonists: Aza ω-Chain Analogues

A novel bicyclic prostaglandin analogue, >-7-acetyl>amino>methyl>-7-oxabicyclohept-2-yl>-5-heptenoic acid ((-)-7) was found to be a potent and selective thromboxane A2 (TxA2) receptor antagonist.Unlike the related series of ω-chain allylic alcohols, amide 7 and its congeners were uniformly free of direct contractile activity in vitro (bovine coronary) and in vivo (anesthetized guinea pig).Amide 7 was effective in the inhibition of (a) arachidonic acid induced platelet aggregation of human platelet-richplasma (I50 = 0.18 +/- 0.006 μM), (b) 11,9-epoxymethano-PGH2 induced platelet aggregation of human platelet-rich plasma (I50 = 0.24 μM), (c) 11,9-epoxymethano-PGH2 induced contraction of guinea pig trachea (Kb = 3.0 +/- 0.3 nM) or rat aorta (Kb = 8.8 +/- 1.1 nM), and (d) arachidonic acid induced bronchoconstriction in the anesthetized guinea pig (0.1-1.0 mg/kg iv).Amide 7 inhibited the binding of ->-7-hydrazino>methyl>-7-oxabicyclohept-2-yl>-5-heptenoic acid to human platelet membranes in a specific and saturable manner with a Kd = 49.6 +/- 1.4 nM.