128790-76-1

Upstream product

• 961-07-9 2'-deoxyguanosine 
• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 961-07-9 2'-Deoxyguanosine 

Downstream Products

• 4546-70-7 2-amino-2'-deoxyadenosine 
• 964-21-6 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine 
• 155866-56-1 Toluene-4-sulfonic acid (2R,3S,5R)-3-hydroxy-5-[6-pentafluorophenyloxy-2-(2,2,2-trifluoro-acetylamino)-purin-9-yl]-tetrahydro-furan-2-ylmethyl ester 

Relevant academic research and scientific papers

Synthesis of 6-substituted 2'-deoxyguanosine derivatives using trifluoroacetic anhydride in pyridine

Trifluoroacetic anhydride at 0°C reacts with a pyridine suspension of deoxyguanosine to generate a polar intermediate, presumably the corresponding 6-pyridyl derivative. The reaction is complete in less than 15 minutes, and is not accompanied by degradation. From this intermediate a variety of 6-substituted deoxyguanosine derivatives can be obtained, some in excellent yields.

Porphyrinyl-nucleosides containing fluorinated nucleobases

Porphyrins were synthesized in which a meso-p-phenylene-O-bridge joins the porphine core with 5'-C of 5-fluorouridine (protected), 5-CF3-thymidine or 2-N-trifluoroacetamidato-6-O-pentafluorophenyl-2'-deoxyguanosine.