128807-56-7

Upstream product

• 99-91-2 para-chloroacetophenone 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 536-74-3 phenylacetylene 
• 275371-05-6 2-bromo-2-(4-chloro-phenyl)-N-methoxy-acetamide 
• 275371-07-8 2-bromo-N-methoxy-2-phenyl-acetamide 
• 102862-20-4 3-(4-Chloro-phenyl)-imidazo[1,2-a]pyridin-2-ol 
• 110520-35-9 N'-(2-Bromo-2-phenyl-acetyl)-hydrazinecarboxylic acid methyl ester 

Relevant academic research and scientific papers

Facile Synthesis of γ-Butenolides and Maleic Anhydrides via Annulation of α-Keto Acids and Triazenyl Alkynes

A facile synthesis of γ-butenolides and maleic anhydrides via annulation of α-keto acids and triazenyl alkynes is described. In this process, α-keto acids and triazenyl alkynes could undergo a self-catalyzed annulation at room temperature to deliver γ-butenolides efficiently, while the further addition of BF3-Et2O furnished maleic anhydrides. Overall, these processes have mild reaction conditions, broad scope, and high efficiency.

Synthesis in a stage of N-methoxyindolinones, N-methoxymaleimides and maleic anhydrides starting from α-halogen hydroxamic acids

α-Halo hydroxamic acids were used in the synthesis of N-methoxyindolinones, symmetric and dissymmetric N-methoxymaleimides in good yields. The hydrolysis of N-methoxymaleimides constitues a new and good route to maleic anhydrides.

SYNTHESE DE N-AMINO MALEIMIDES ET D'ANHYDRIDES MALEIQUES DISUBSTITUES A PARTIR D'α-HALOGENO HYDRAZIDES. ETUDE DU MECANISME DE LA REACTION.

α-Halohydrazides react with 2-aminopyridine to give symmetrically substituted N-aminomaleimides.We have shown that this reaction proceeds through the formation of 4-hydroxyimidazopyridines.This result opens a new route to dissymetrically substituted N-aminomaleimides.The hydrolysis of N-aminomaleimides is a grood route to substituted maleic anhydrides.