128821-01-2Relevant articles and documents
Diastereoselective Synthesis of Functionalized 9-Ring Ethers (Oxonins).
Brandes, Arndt,Hoffmann, H. M. R.
, p. 145 - 154 (1995)
In response to the challenge of preparing medium ring ethers of the Laurencia class, a simple synthesis of functionalized, acyclic α,α'-chiral disecondary ethers has been developed.Stereocontrolled cyclization to 9-membered rings was effected in overall h
HYDROXAMATE COMPOUNDS AS ANTAGONISTS OF THE ADENOSINE A2A RECEPTOR
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Paragraph 00544, (2021/01/23)
The present invention relates to compounds of formula I shown below: (I) wherein R1, R2 and R3 are each as defined in the application. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or conditions in which adenosine A2a receptor activity is implicated, such as, for example, cancer.
COMPOSITIONS, SYNTHESIS, AND METHODS OF USING PHENYLCYCLOALKYLMETHYLAMINE DERIVATIVES
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Page/Page column 53-54, (2013/07/19)
The present invention provides novel phenylcycloalkylmethylamme derivatives, and methods of preparing phenylcycloalkylmethylamme derivatives. The present invention also provides methods of using phenylcycloalkylmethylamme derivatives and compositions of phenylcycloalkylmethylamme derivatives. The pharmaceutical compositions of the compounds of the present invention can be used for treating and/or preventing obesity and obesity related co- morbid indications and depression and depression related co-morbid indications.
Copper(I)-catalyzed asymmetric desymmetrization: Synthesis of five-membered-ring compounds containing all-carbon quaternary stereocenters
Aikawa, Kohsuke,Okamoto, Tatsuya,Mikami, Koichi
supporting information; experimental part, p. 10329 - 10332 (2012/07/30)
A highly stereoselective catalytic alkylation sequence for the synthesis of highly functionalized and versatile five-membered-ring compounds bearing all-carbon quaternary stereocenters was developed. Enantioselective desymmetrization of achiral cyclopentene-1,3-diones was thus executed by chiral Cu-phosphoramidite catalysts. A variety of complicated cyclopentane derivatives can be synthesized with excellent stereoselectivities using a low catalyst loading in a one-pot operation.