128823-23-4

Basic information

• Product Name: dimethyl 2-(2-iodophenyl)-malonate
• Synonyms: dimethyl 2-(2-iodophenyl)-malonate
• CAS NO: 128823-23-4
• Molecular Weight: 334.11
• Mol File: 128823-23-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: dimethyl 2-(2-iodophenyl)-malonate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 2-(2-iodophenyl)-malonate(128823-23-4)
• EPA Substance Registry System: dimethyl 2-(2-iodophenyl)-malonate(128823-23-4)

Safety Data

• Hazardous Substances Data: 128823-23-4(Hazardous Substances Data)

Upstream product

• 18698-96-9 o-iodophenylacetic acid 
• 36719-71-8 (E)-1-phenyl-2-(pyrrolidin-1-yl)diazene 
• 6773-29-1 dimethyl diazomalonate 
• 66370-75-0 methyl (2-iodophenyl)acetate 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 1186611-33-5 C₁₆H₂₀O₄Si 

Relevant articles and documents

Rh(III)-catalyzed aromatic C-H bond carbenoid functionalization of triazenes by α-diazomalonate

A Rh(III)-catalyzed aromatic C-H bond carbenoid functionalization of triazenes by α-diazomalonates has been developed, with features of mild reaction condition and high efficiency. Furthermore, the functionalized triazenes could be subject to divergent synthesis.

Copper-Catalyzed Intramolecular Desymmetric Aryl C-O Coupling for the Enantioselective Construction of Chiral Dihydrobenzofurans and Dihydrobenzopyrans

O-Heterocyclic structures such as 2,3-dihydrobenzofurans are key motifs in many natural compounds and pharmaceuticals. Enantioselective formation of chiral dihydrobenzofurans and analogues was achieved through a copper-catalyzed desymmetrization strategy with a chiral cyclic 1,2-diamine. A broad range of substrates are compatible with this CuI-diamine catalytic system and afford the desired coupling products with chiral tertiary or quaternary carbon centers in high yields and good to excellent enantioselectivities under mild conditions. O-Heterocyclic structures such as chiral dihydrobenzofurans can be formed enantioselectively through a copper-catalyzed desymmetrization strategy with a chiral cyclic 1,2-diamine ligand. A broad range of substrates is compatible with this CuI-diamine catalytic system and afford the desired coupling products with chiral tertiary or quaternary carbon centers in high yields and good to excellent enantioselectivities under mild conditions.

Formal total synthesis of (-)-physostigmine

The formal total synthesis of (-)-physostigmine via the chiral malonic acid mono-ester ((R)-2-(2-chlorophenyl)-2-methoxycarbonylpropanoic acid, 99% ee) newly prepared by the pig liver esterase (PLE) mediated asymmetric hydrolysis of the corresponding di-e