Fmoc-D-Asp(OtBu)-OH is a specialized chemical compound utilized in peptide synthesis, featuring an aspartic acid amino acid with a fluorenylmethyloxycarbonyl (Fmoc) protective group on the amino group and a tert-butoxycarbonyl (OtBu) protective group on the side chain carboxylic acid. These protective groups are crucial for the synthesis process, ensuring the correct sequence and structure of the resulting peptide.
12883-39-3
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Basic information
- Product Name: Fmoc-D-Asp(OtBu)-OH
- Synonyms: N-FMOC-D-asparticacid-t-butylester;D-ASPARTIC ACID, N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-, 4-(1,1-DIMETHYLETHYL) ESTER;Fmoc-D-aspartic acid β-tert.buty ester
- CAS NO:12883-39-3
- Molecular Formula: C23H25NO6
- Molecular Weight: 411.4477
- EINECS: N/A
- Product Categories: Fmoc-Amino Acids and Derivatives;Fmoc-Amino acid series
- Mol File: 12883-39-3.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Fmoc-D-Asp(OtBu)-OH(CAS DataBase Reference)
- NIST Chemistry Reference: Fmoc-D-Asp(OtBu)-OH(12883-39-3)
- EPA Substance Registry System: Fmoc-D-Asp(OtBu)-OH(12883-39-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 12883-39-3(Hazardous Substances Data)
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12883-39-3 Usage
Uses
Used in Pharmaceutical Industry:Fmoc-D-Asp(OtBu)-OH is used as a building block in the solid-phase peptide synthesis process for creating specific peptide sequences. The Fmoc group protects the amine group, facilitating controlled peptide chain elongation, while the OtBu group shields the carboxylic acid group of aspartic acid, preventing unwanted side reactions.
Used in Research and Development:
In the field of research, Fmoc-D-Asp(OtBu)-OH is employed as a reagent for the synthesis of bioactive peptides and peptidomimetics. Its use allows for the exploration of novel peptide-based therapeutics and the study of peptide structure-function relationships.
Used in Biochemistry and Molecular Biology:
Fmoc-D-Asp(OtBu)-OH is utilized in the preparation of peptides for various biochemical and molecular biology applications, such as enzyme inhibitors, receptor ligands, and components of vaccine formulations. Its role in peptide synthesis is essential for the development of these biological tools and therapeutic agents.
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Fmoc-D-Asp(OtBu)-OH
