128831-46-9 Usage
Chemical class
Urea class of compounds
Target enzyme
Potent and selective inhibitor of histone deacetylase 6 (HDAC6)
Biological role
Regulation of gene expression, cellular proliferation, and other important biological processes
Potential therapeutic applications
Treatment of various cancers, including multiple myeloma and lymphoma
Mechanism of action
Inhibits the growth and survival of cancerous cells
Additional research areas
Treatment of neurodegenerative diseases and inflammatory conditions
Mode of action in additional research
Modulates the immune response and reduces inflammation
Current status
Interest as a potential therapeutic agent for a variety of conditions
Ongoing activities
Subject of ongoing research and clinical trials
Check Digit Verification of cas no
The CAS Registry Mumber 128831-46-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,8,3 and 1 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 128831-46:
(8*1)+(7*2)+(6*8)+(5*8)+(4*3)+(3*1)+(2*4)+(1*6)=139
139 % 10 = 9
So 128831-46-9 is a valid CAS Registry Number.
InChI:InChI=1/C24H18ClF2N3O/c1-13-9-17-21(10-14(13)2)28-12-22(23(17)16-5-3-4-6-18(16)25)30-24(31)29-20-8-7-15(26)11-19(20)27/h3-12H,1-2H3,(H2,29,30,31)
128831-46-9Relevant articles and documents
Quinoline derivatives, their production and use
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, (2008/06/13)
Quinoline derivatives of the formula: STR1 , wherein R is hydrogen, alkyl or aralkyl; m and n are 0 or 1, and each of rings A, B and C can have substituents, which are useful as inhibitors for acyl-CoA:Cholesterolacyltransferase.
