128855-31-2Relevant academic research and scientific papers
Total synthesis of (+)-leukotriene B4 methyl ester and its 5-epimer from (R)-glycidol
Avignon-Tropis,Treilhou,Pougny,Frechard-Ortuno,Linstrumelle
, p. 7279 - 7286 (2007/10/02)
The Pd-Cu coupling reaction of a chiral hydroxy-(E,E)-iododiene with a racemic acetylenic alcohol followed by reduction of the dienyne leads to the desired (Z,E,E) geometry and allows synthesis of LTB4 and its 5-epimer after separation of diast
An efficient synthesis of leukotriene B4
Avignon-Tropis,Treilhou,Lebreton,Pougny,Frechard-Ortuno,Huynh,Linstrumelle
, p. 6335 - 6336 (2007/10/02)
Leukotriene B4 (5S, 12R) and its epimer (5R, 12R) have been prepared by coupling a chiral hydroxy vinyl borane with a racemic vinyl iodide, followed by the easy separation of the thus formed diastereomers.
