128858-43-5

Basic information

• Product Name: Di-p-Chlorobenzyl N,N-Diisopropylphosphoramidite
• Synonyms: Bis(1-Methylethyl)phosphoraMidous Acid Bis[(4-chlorophenyl)Methyl] Ester
• CAS NO: 128858-43-5
• Molecular Formula: C₂₀H₂₆Cl₂NO₂P
• Molecular Weight: 414.31
• Product Categories: Phospholipids - 13C & 2H;Phosphorylating and Phosphitylating Agents
• Mol File: 128858-43-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 427.9°C at 760 mmHg
• Flash Point: 212.6°C
• Appearance: /
• Vapor Pressure: 1.58E-07mmHg at 25°C
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Stability: Moisture Sensitive
• CAS DataBase Reference: Di-p-Chlorobenzyl N,N-Diisopropylphosphoramidite(CAS DataBase Reference)
• NIST Chemistry Reference: Di-p-Chlorobenzyl N,N-Diisopropylphosphoramidite(128858-43-5)
• EPA Substance Registry System: Di-p-Chlorobenzyl N,N-Diisopropylphosphoramidite(128858-43-5)

Safety Data

• Hazardous Substances Data: 128858-43-5(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Oil

Uses

A versatile phosphitylating agent for the phosphorylation of hydroxy amino acids and the preparation of protected phosphopeptides

InChI:InChI=1/C20H26Cl2NO2P/c1-15(2)23(16(3)4)26(24-13-17-5-9-19(21)10-6-17)25-14-18-7-11-20(22)12-8-18/h5-12,15-16H,13-14H2,1-4H3

Upstream product

• 921-26-6 N,N-diisopropylphosphoramide dichloride 
• 873-76-7 para-Chlorobenzyl alcohol 

Downstream Products

• 128858-39-9 (S)-3-{4-[Bis-(4-chloro-benzyloxy)-phosphoryloxy]-phenyl}-2-((S)-2-tert-butoxycarbonylamino-propionylamino)-propionic acid methyl ester 
• 128858-38-8 (2S,3R)-3-[Bis-(4-chloro-benzyloxy)-phosphoryloxy]-2-((S)-2-tert-butoxycarbonylamino-propionylamino)-butyric acid methyl ester 
• 128858-37-7 (S)-3-[Bis-(4-chloro-benzyloxy)-phosphoryloxy]-2-((S)-2-tert-butoxycarbonylamino-propionylamino)-propionic acid methyl ester 
• 128858-33-3 (S)-3-{4-[Bis-(4-chloro-benzyloxy)-phosphoryloxy]-phenyl}-2-tert-butoxycarbonylamino-propionic acid methyl ester 
• 128858-32-2 (2S,3R)-3-[Bis-(4-chloro-benzyloxy)-phosphoryloxy]-2-tert-butoxycarbonylamino-butyric acid methyl ester 
• 128858-31-1 (S)-3-[Bis-(4-chloro-benzyloxy)-phosphoryloxy]-2-tert-butoxycarbonylamino-propionic acid methyl ester 
• 651719-24-3 (E)-(2S,5S,8S,11S,14S)-2-{4-[Bis-(4-chloro-benzyloxy)-phosphoryloxy]-benzyl}-8-carbamoylmethyl-5,11-diisopropyl-3,6,9,12,20-pentaoxo-1,4,7,10,13-pentaaza-cycloicos-16-ene-14-carboxylic acid methyl ester 
• 1054617-94-5 Phosphorous acid (1R,2S,3R,4R,5S)-2-benzyloxy-3,4,5-tris-[bis-(4-chloro-benzyloxy)-phosphanyloxy]-cyclohexyl ester bis-(4-chloro-benzyl) ester 
• 147019-85-0 N-benzoyl-O-serine benzylamide 
• 1027489-76-4 (2S,3R)-3-[Bis-(4-chloro-benzyloxy)-phosphanyloxy]-2-tert-butoxycarbonylamino-butyric acid methyl ester 
• 1026330-12-0 (S)-3-[Bis-(4-chloro-benzyloxy)-phosphanyloxy]-2-tert-butoxycarbonylamino-propionic acid methyl ester 
• 1027147-60-9 (S)-3-{4-[Bis-(4-chloro-benzyloxy)-phosphanyloxy]-phenyl}-2-tert-butoxycarbonylamino-propionic acid methyl ester 
• 133843-93-3 di(3-chlorobenzyl) isobutyl phosphate 

Relevant articles and documents

Synthesis of Casein-Related Peptides and Phosphopeptides. X A Modified Method for the Synthesis of Ser(P)-Containing Peptides Through 4-Bromobenzyl Phosphate Protection

The three 4-halobenzyl phosphoramidite reagents di(4-fluorobenzyl) N,N-diisopropylphosphoramidite, di(4-chlorobenzyl) N,N-diisopropylphosphoramidite and di(4-bromobenzyl) N,N-diethylphosphoramidite were prepared and used for the efficient phosphite-triest