128861-76-7

Basic information

• Product Name: THIETAN-3-YLAMINE HYDROBROMIDE
• Synonyms: THIETAN-3-YLAMINE HYDROBROMIDE;3-Thietanamine;3-Thiacyclobutylamin;thietan-3-amine
• CAS NO: 128861-76-7
• Molecular Formula: C₃H₇NS
• Molecular Weight: 170.073
• Mol File: 128861-76-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 148.5 °C at 760 mmHg
• Flash Point: 43.6 °C
• Appearance: /
• Density: 1.142
• PKA: 7.00±0.20(Predicted)
• CAS DataBase Reference: THIETAN-3-YLAMINE HYDROBROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: THIETAN-3-YLAMINE HYDROBROMIDE(128861-76-7)
• EPA Substance Registry System: THIETAN-3-YLAMINE HYDROBROMIDE(128861-76-7)

Safety Data

• Hazardous Substances Data: 128861-76-7(Hazardous Substances Data)

Usage

Uses

3-Thietanamine is an analog of cyclamate, an aritficial sweetener.

Upstream product

• 1418193-22-2 3-pyridinium-thietane p-toluenesulfonate 
• 1418193-20-0 thietan-3-yl-azide 
• 1418193-23-3 thietan-3-ylcarbamic acid methyl ester 
• 128861-77-8 3-Thiacyclobutanon-oxim 

Downstream Products

• 1424279-69-5 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethyl-N-(thietan-3-yl)benzamide 
• 1424279-75-3 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-nitro-N-(thietan-3-yl)benzamide 
• 1427273-64-0 4-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isothiazol-3-yl]-2-methyl-N-thietan-3-yl-benzamide 
• 1424279-91-3 2-methyl-N-(thietan-3-yl)-4-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]benzamide 
• 1352242-60-4 C₂₂H₁₉Cl₂F₃N₂OS 

Relevant articles and documents

PROCESSES FOR THE PREPARATION OF THIETANAMINE

The present invention provides processes for the preparation of compounds of formula (I) including processes comprising a. reacting a compound of formula (II) with a nucleophile in the presence of water to give a compound comprising a thietane moiety in which the carbon atom at the 3 position of the thietane moiety is bonded to a nitrogen atom; wherein the nucleophile is selected the group consisting of: N3-, a sulfonamide having two hydrogen atoms bound to the nitrogen atom, a diimide having a hydrogen atom bound to the nitrogen atom or an anion thereof, NH2OH and NH3; and b. when the nucleophile used in step a. is N3- or NH2OH, reacting the compound produced in step a. with a suitable reducing agent to give a compound of formula (I); or when the nucleophile used in step a. is a sulfonamide, reacting the compound produced in step a. with a reagent suitable for cleaving the S-N bond of the sulfonamide group to give a compound of formula (I); or when the nucleophile used in step a. is a diimide, reacting the compound produced in step a. with a reagent suitable for cleaving the C-N bond of the amide group to give a compound of formula (I). The invention also relates to intermediates useful for the preparation of compounds of formula (I).

Synthesis of thia-analogous cyclamates

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